High-throughput screening of catalytically inactive mutants of protein tyrosine phosphatases (PTPs) in a phosphopeptide microarray

Hongyan Sun; Lay Pheng Tan; Liqian Gao; Shao Q. Yao

doi:10.1039/b817853d

High-throughput screening of catalytically inactive mutants of protein tyrosine phosphatases (PTPs) in a phosphopeptide microarray

Hongyan Sun, Lay Pheng Tan, Liqian Gao, Shao Q. Yao

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

46 Citations (Scopus)

Abstract

We report herein a novel phosphopeptide microarray capable of noncovalently "trapping" catalytically inactive mutants of protein tyrosine phosphatases (PTPs), and its application in high-throughput determination of PTP substrate specificity. © The Royal Society of Chemistry 2009.

Original language	English
Pages (from-to)	677-679
Journal	Chemical Communications
Issue number	6
DOIs	https://doi.org/10.1039/b817853d
Publication status	Published - 2009
Externally published	Yes

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title = "High-throughput screening of catalytically inactive mutants of protein tyrosine phosphatases (PTPs) in a phosphopeptide microarray",

abstract = "We report herein a novel phosphopeptide microarray capable of noncovalently {"}trapping{"} catalytically inactive mutants of protein tyrosine phosphatases (PTPs), and its application in high-throughput determination of PTP substrate specificity. {\textcopyright} The Royal Society of Chemistry 2009.",

author = "Hongyan Sun and Tan, {Lay Pheng} and Liqian Gao and Yao, {Shao Q.}",

year = "2009",

doi = "10.1039/b817853d",

language = "English",

pages = "677--679",

journal = "Chemical Communications",

issn = "0009-241X",

publisher = "Royal Society of Chemistry",

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T1 - High-throughput screening of catalytically inactive mutants of protein tyrosine phosphatases (PTPs) in a phosphopeptide microarray

AU - Sun, Hongyan

AU - Tan, Lay Pheng

AU - Gao, Liqian

AU - Yao, Shao Q.

PY - 2009

Y1 - 2009

N2 - We report herein a novel phosphopeptide microarray capable of noncovalently "trapping" catalytically inactive mutants of protein tyrosine phosphatases (PTPs), and its application in high-throughput determination of PTP substrate specificity. © The Royal Society of Chemistry 2009.

AB - We report herein a novel phosphopeptide microarray capable of noncovalently "trapping" catalytically inactive mutants of protein tyrosine phosphatases (PTPs), and its application in high-throughput determination of PTP substrate specificity. © The Royal Society of Chemistry 2009.

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UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-58849085891&origin=recordpage

U2 - 10.1039/b817853d

DO - 10.1039/b817853d

M3 - RGC 21 - Publication in refereed journal

C2 - 19322419

SN - 0009-241X

SP - 677

EP - 679

JO - Chemical Communications

JF - Chemical Communications

IS - 6

ER -

High-throughput screening of catalytically inactive mutants of protein tyrosine phosphatases (PTPs) in a phosphopeptide microarray

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