High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy

Andy K.S. Lau; Anson H.L. Tang; Bob M.F. Chung; P. Yeung; Xiaoming Wei; Barbara P. Chan; H. C. Shum; Kenneth K.Y. Wong; Kevin K. Tsia

doi:10.1364/boda.2015.bw1a.4

High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy

Andy K.S. Lau^*, Anson H.L. Tang, Bob M.F. Chung, P. Yeung, Xiaoming Wei, Barbara P. Chan, H. C. Shum, Kenneth K.Y. Wong, Kevin K. Tsia

^*Corresponding author for this work

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

2 Citations (Scopus)

Abstract

We report imaged-based intrinsic light-scattering single-cell analysis enabled by ultrafast asymmetric-detection time-stretch optical microscopy (line-scan rate >10 MHz) - achieving high-quality dual-contrast images with subcellular resolution at an imaging throughput of 120,000 cells/sec. © OSA 2015.

Original language	English
Title of host publication	Bio-Optics: Design and Application, BODA 2015
Publisher	Optical Society of America (OSA)
ISBN (Print)	9781557529541
DOIs	https://doi.org/10.1364/boda.2015.bw1a.4
Publication status	Published - 6 Apr 2015
Externally published	Yes
Event	Bio-Optics: Design and Application, BODA 2015 - Vancouver, Canada Duration: 12 Apr 2015 → 15 Apr 2015 https://www.osapublishing.org/conference.cfm?meetingid=121&yr=2015

Conference

Conference	Bio-Optics: Design and Application, BODA 2015
Place	Canada
City	Vancouver
Period	12/04/15 → 15/04/15
Internet address	https://www.osapublishing.org/conference.cfm?meetingid=121&yr=2015

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

This work is partially supported by grants from the Research Grants Council of Hong Kong Special Administrative Region, China (HKU 717911E, HKU 720112E, and 17207714), ITS/090/14 Innovation and Technology Support Programme (Tier 3) and the University Development Fund of HKU.

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10.1364/boda.2015.bw1a.4

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Lau, A. K. S., Tang, A. H. L., Chung, B. M. F., Yeung, P., Wei, X., Chan, B. P., Shum, H. C., Wong, K. K. Y., & Tsia, K. K. (2015). High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy. In Bio-Optics: Design and Application, BODA 2015 Optical Society of America (OSA). https://doi.org/10.1364/boda.2015.bw1a.4

@inproceedings{a2bc06f1af9c439884fb481a65c7768f,

title = "High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy",

abstract = "We report imaged-based intrinsic light-scattering single-cell analysis enabled by ultrafast asymmetric-detection time-stretch optical microscopy (line-scan rate >10 MHz) - achieving high-quality dual-contrast images with subcellular resolution at an imaging throughput of 120,000 cells/sec. {\textcopyright} OSA 2015.",

author = "Lau, {Andy K.S.} and Tang, {Anson H.L.} and Chung, {Bob M.F.} and P. Yeung and Xiaoming Wei and Chan, {Barbara P.} and Shum, {H. C.} and Wong, {Kenneth K.Y.} and Tsia, {Kevin K.}",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].; Bio-Optics: Design and Application, BODA 2015 ; Conference date: 12-04-2015 Through 15-04-2015",

year = "2015",

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doi = "10.1364/boda.2015.bw1a.4",

language = "English",

isbn = "9781557529541",

booktitle = "Bio-Optics: Design and Application, BODA 2015",

publisher = "Optical Society of America (OSA)",

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Lau, AKS, Tang, AHL, Chung, BMF, Yeung, P, Wei, X, Chan, BP, Shum, HC, Wong, KKY & Tsia, KK 2015, High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy. in Bio-Optics: Design and Application, BODA 2015. Optical Society of America (OSA), Bio-Optics: Design and Application, BODA 2015, Vancouver, Canada, 12/04/15. https://doi.org/10.1364/boda.2015.bw1a.4

High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy. / Lau, Andy K.S.; Tang, Anson H.L.; Chung, Bob M.F. et al.
Bio-Optics: Design and Application, BODA 2015. Optical Society of America (OSA), 2015.

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 32 - Refereed conference paper (with host publication) › peer-review

TY - GEN

T1 - High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy

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AU - Tang, Anson H.L.

AU - Chung, Bob M.F.

AU - Yeung, P.

AU - Wei, Xiaoming

AU - Chan, Barbara P.

AU - Shum, H. C.

AU - Wong, Kenneth K.Y.

AU - Tsia, Kevin K.

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AB - We report imaged-based intrinsic light-scattering single-cell analysis enabled by ultrafast asymmetric-detection time-stretch optical microscopy (line-scan rate >10 MHz) - achieving high-quality dual-contrast images with subcellular resolution at an imaging throughput of 120,000 cells/sec. © OSA 2015.

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M3 - RGC 32 - Refereed conference paper (with host publication)

SN - 9781557529541

BT - Bio-Optics: Design and Application, BODA 2015

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T2 - Bio-Optics: Design and Application, BODA 2015

Y2 - 12 April 2015 through 15 April 2015

ER -

High-throughput image-based single-cell analysis by ultrafast asymmetric-detection time-stretch optical microscopy

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