High performance shape memory foams with isocyanate-modified hydroxyapatite nanoparticles for minimally invasive bone regeneration

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

32 Scopus Citations
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  • Ruiqi Xie
  • Frankie Ng
  • Lin Tan
  • Tingwu Qin
  • Mingqiu Zhang
  • Xia Guo


Original languageEnglish
Pages (from-to)4794-4802
Journal / PublicationCeramics International
Issue number6
Online published8 Dec 2016
Publication statusPublished - 15 Apr 2017
Externally publishedYes


This study conducts a comprehensive assessment of shape memory polyurethane (SMPU) composite foams with isocyanate-modified hydroxyapatite (imHA) nanoparticles in terms of their pore structures, mechanical properties, shape memory effects and biocompatibility in vitro. The results obtained in the research reveal the effectiveness of imHA nanoparticles in SMPU foams as inorganic cross-linking fillers, which contribute to the enhancement of mechanical properties and shape memory performance. Pore structures and compressive properties are simultaneously optimized when imHA content increases. The imHA enhanced SMPU foam could be adopted as a promising alternative for overcoming the disadvantages of traditional polymer scaffolds, such as insufficient mechanical properties, inadequate pore structure, low bioactivity and inconvenience in operation for bone regeneration.

Research Area(s)

  • A. Composites, B. Mechanical properties, B. Thermomechanical properties, Isocyanate-modified hydroxyapatite

Citation Format(s)