High-performance nonenzymatic creatinine detection by Cu-MOF@MXene electrochemical sensor

Xianglong Bian; Dong Yang; Lin Chen; Yingfei Zeng; Li Zhu; Hua Pei; Qianfeng Xia; Paul K. Chu; Tingwei Hu

doi:10.1016/j.microc.2025.114915

High-performance nonenzymatic creatinine detection by Cu-MOF@MXene electrochemical sensor

Xianglong Bian (Co-first Author), Dong Yang (Co-first Author), Lin Chen, Yingfei Zeng, Li Zhu, Hua Pei, Qianfeng Xia, Paul K. Chu^*, Tingwei Hu^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

5 Citations (Scopus)

Abstract

Creatinine serves as a crucial biomarker for various diseases, and the development of effective and stable nonezymatic sensor is essential due to the limitations of enzyme-based biosensors, such as poor conductivity and environmental instability. In this study, a composite material comprising a copper organic framework and MXene (Cu-MOF@MXene) is synthesized through a one-step reaction, enabling enzyme-free electrochemical sensing of creatinine. The Cu-MOF@MXene sensor demonstrates good linearity within the range of 20.0 μM to 150.0 μM and a low detection limit (LOD) of 20.069 μM. A screen-printed electrode (SPE) coated with Cu-MOF@MXene is fabricated for monitoring urine and human serum samples. The results indicate that the SPE possesses high sensitivity, selectivity, and stability for nonenzymatic creatinine detection, highlighting potential advancement in clinical testing and medical diagnostics. © 2025 Elsevier B.V.

Original language	English
Article number	114915
Journal	Microchemical Journal
Volume	217
Online published	19 Aug 2025
DOIs	https://doi.org/10.1016/j.microc.2025.114915
Publication status	Published - Oct 2025

Funding

This work was jointly supported by the Hainan Provincial Natural Science Foundation of China (No. 521RC555 ), Special Talent Researching Funds ( RZ2500001778 , RC2400001279 , XRC200016 ), and City University of Hong Kong Donation Research Grants (DON-RMG 9229021 and 9220061 ).

Research Keywords

Creatinine detection
Cu-MOF@MXene
Nonenzymatic electrochemical sensor

Access Output

10.1016/j.microc.2025.114915

Other Access Options

Check CityUHK Library

Permanent Link

Right click to copy link

Cite this

@article{4f6e70d6dd5c42fdad5f1dc2dee05516,

title = "High-performance nonenzymatic creatinine detection by Cu-MOF@MXene electrochemical sensor",

abstract = "Creatinine serves as a crucial biomarker for various diseases, and the development of effective and stable nonezymatic sensor is essential due to the limitations of enzyme-based biosensors, such as poor conductivity and environmental instability. In this study, a composite material comprising a copper organic framework and MXene (Cu-MOF@MXene) is synthesized through a one-step reaction, enabling enzyme-free electrochemical sensing of creatinine. The Cu-MOF@MXene sensor demonstrates good linearity within the range of 20.0 μM to 150.0 μM and a low detection limit (LOD) of 20.069 μM. A screen-printed electrode (SPE) coated with Cu-MOF@MXene is fabricated for monitoring urine and human serum samples. The results indicate that the SPE possesses high sensitivity, selectivity, and stability for nonenzymatic creatinine detection, highlighting potential advancement in clinical testing and medical diagnostics. {\textcopyright} 2025 Elsevier B.V.",

keywords = "Creatinine detection, Cu-MOF@MXene, Nonenzymatic electrochemical sensor",

author = "Xianglong Bian and Dong Yang and Lin Chen and Yingfei Zeng and Li Zhu and Hua Pei and Qianfeng Xia and Chu, {Paul K.} and Tingwei Hu",

year = "2025",

month = oct,

doi = "10.1016/j.microc.2025.114915",

language = "English",

volume = "217",

journal = "Microchemical Journal",

issn = "0026-265X",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - High-performance nonenzymatic creatinine detection by Cu-MOF@MXene electrochemical sensor

AU - Bian, Xianglong

AU - Yang, Dong

AU - Chen, Lin

AU - Zeng, Yingfei

AU - Zhu, Li

AU - Pei, Hua

AU - Xia, Qianfeng

AU - Chu, Paul K.

AU - Hu, Tingwei

PY - 2025/10

Y1 - 2025/10

N2 - Creatinine serves as a crucial biomarker for various diseases, and the development of effective and stable nonezymatic sensor is essential due to the limitations of enzyme-based biosensors, such as poor conductivity and environmental instability. In this study, a composite material comprising a copper organic framework and MXene (Cu-MOF@MXene) is synthesized through a one-step reaction, enabling enzyme-free electrochemical sensing of creatinine. The Cu-MOF@MXene sensor demonstrates good linearity within the range of 20.0 μM to 150.0 μM and a low detection limit (LOD) of 20.069 μM. A screen-printed electrode (SPE) coated with Cu-MOF@MXene is fabricated for monitoring urine and human serum samples. The results indicate that the SPE possesses high sensitivity, selectivity, and stability for nonenzymatic creatinine detection, highlighting potential advancement in clinical testing and medical diagnostics. © 2025 Elsevier B.V.

AB - Creatinine serves as a crucial biomarker for various diseases, and the development of effective and stable nonezymatic sensor is essential due to the limitations of enzyme-based biosensors, such as poor conductivity and environmental instability. In this study, a composite material comprising a copper organic framework and MXene (Cu-MOF@MXene) is synthesized through a one-step reaction, enabling enzyme-free electrochemical sensing of creatinine. The Cu-MOF@MXene sensor demonstrates good linearity within the range of 20.0 μM to 150.0 μM and a low detection limit (LOD) of 20.069 μM. A screen-printed electrode (SPE) coated with Cu-MOF@MXene is fabricated for monitoring urine and human serum samples. The results indicate that the SPE possesses high sensitivity, selectivity, and stability for nonenzymatic creatinine detection, highlighting potential advancement in clinical testing and medical diagnostics. © 2025 Elsevier B.V.

KW - Creatinine detection

KW - Cu-MOF@MXene

KW - Nonenzymatic electrochemical sensor

UR - http://www.scopus.com/inward/record.url?scp=105014015429&partnerID=8YFLogxK

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-105014015429&origin=recordpage

U2 - 10.1016/j.microc.2025.114915

DO - 10.1016/j.microc.2025.114915

M3 - RGC 21 - Publication in refereed journal

SN - 0026-265X

VL - 217

JO - Microchemical Journal

JF - Microchemical Journal

M1 - 114915

ER -

High-performance nonenzymatic creatinine detection by Cu-MOF@MXene electrochemical sensor

Abstract

Funding

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

DON_RMG: Fabrication, Characterization, and Properties of Functional Materials - RMGS

DON: Surface Modification and Fabrication of Advanced Materials

Cite this

High-performance nonenzymatic creatinine detection by Cu-MOF@MXene electrochemical sensor

Abstract

Funding

Research Keywords

Access Output

Other Access Options

Permanent Link

Other Files and Links

Fingerprint

Projects

DON_RMG: Fabrication, Characterization, and Properties of Functional Materials - RMGS

DON: Surface Modification and Fabrication of Advanced Materials

Cite this