High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

17 Scopus Citations
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Author(s)

  • Arjen H.G. Cleven
  • Valentina Nardi
  • Chi Young Ok
  • Maitrayee Goswami
  • Paola Dal Cin
  • A John Iafrate
  • Myrurgia A. Abdul Hamid
  • Sa A. Wang
  • Robert P. Hasserjian

Detail(s)

Original languageEnglish
Pages (from-to)552-563
Journal / PublicationModern Pathology
Volume28
Issue number4
Publication statusPublished - 8 Apr 2015
Externally publishedYes

Abstract

Identification of p53-positive cells by immunohistochemistry in bone marrow from primary myelodysplastic syndrome patients correlates with the presence of TP53 mutations and poor prognosis. Mutations in the tumor suppressor gene TP53 are more frequent in therapy-related acute myeloid leukemia and myelodysplastic syndrome than in de novo disease, but the role of p53 immunohistochemistry in the therapy-related setting has not been specifically investigated. We studied p53 protein immunoreactivity in bone marrow biopsies of therapy-related myeloid neoplasms and correlated protein expression with TP53 mutation status, clinicopathologic features and outcome. We first studied 32 patients with therapy-related acute myeloid leukemia and 63 patients with therapy-related myelodysplastic syndrome/chronic myelomonocytic leukemia from one institution and then validated our results in a separate group of 32 patients with therapy-related acute myeloid leukemia and 56 patients with therapy-related myelodysplastic syndrome from a different institution. Strong p53 immunostaining in ≥1% of bone marrow cells was highly predictive of a TP53 gene mutation (P

Citation Format(s)

High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome. / Cleven, Arjen H.G.; Nardi, Valentina; Ok, Chi Young; Goswami, Maitrayee; Dal Cin, Paola; Zheng, Zongli; Iafrate, A John; Abdul Hamid, Myrurgia A.; Wang, Sa A.; Hasserjian, Robert P.

In: Modern Pathology, Vol. 28, No. 4, 08.04.2015, p. 552-563.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review