Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands : Synthesis, Structure, and Multimodal Anticancer Mechanism

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Nikolai F. Romashev
  • Pavel A. Abramov
  • Ivan V. Bakaev
  • Iakov S. Fomenko
  • Denis G. Samsonenko
  • Alexander S. Novikov
  • Kelvin K. H. Tong
  • Dohyun Ahn
  • Pavel V. Dorovatovskii
  • Yan V. Zubavichus
  • Aleksey A. Ryadun
  • Olga A. Patutina
  • Maxim N. Sokolov
  • Artem L. Gushchin

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)2105–2118
Journal / PublicationInorganic Chemistry
Volume61
Issue number4
Online published14 Jan 2022
Publication statusPublished - 31 Jan 2022

Abstract

A series of heteroleptic square-planar Pt and Pd complexes with bis(diisopropylphenyl) iminoacenaphtene (dppBian) and Cl, 1,3-dithia-2-thione-4,5-dithiolate (dmit), or 1,3dithia-2-thione-4,5-diselenolate (dsit) ligands have been prepared and characterized by spectroscopic techniques, elemental analysis, X-ray diffraction analysis, and cyclic voltammetry (CV). The intermolecular noncovalent interactions in the crystal structures were assessed by density functional theory (DFT) calculations. The anticancer activity of Pd complexes in breast cancer cell lines was limited by their solubility. Pd(dpp-Bian) complexes with dmit and dsit ligands as well as an uncoordinated dpp-Bian ligand were devoid of cytotoxicity, while the [Pd(dpp-Bian)Cl2] complex was cytotoxic. On the contrary, all Pt(dpp-Bian) complexes demonstrated anticancer activity in a low micromolar concentration range, which was 8-20 times higher than the activity of cisplatin, and up to 2.5-fold selectivity toward cancer cells over healthy fibroblasts. The presence of a redox-active dpp-Bian ligand in Pt and Pd complexes resulted in the induction of reactive oxygen species (ROS) in cancer cells. In addition, these complexes were able to intercalate into DNA, indicating the dual mechanism of action.

Research Area(s)

  • HETEROCYCLIC CARBENE COMPLEXES, BIDENTATE NITROGEN LIGANDS, COPPER(II) COMPLEXES, PALLADIUM COMPLEXES, PLATINUM COMPLEXES, CISPLATIN, DNA, RAY, DIMERIZATION, OXIDATION

Citation Format(s)

Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands : Synthesis, Structure, and Multimodal Anticancer Mechanism. / Romashev, Nikolai F. ; Abramov, Pavel A.; Bakaev, Ivan V.; Fomenko, Iakov S.; Samsonenko, Denis G.; Novikov, Alexander S.; Tong, Kelvin K. H.; Ahn, Dohyun; Dorovatovskii, Pavel V.; Zubavichus, Yan V.; Ryadun, Aleksey A.; Patutina, Olga A.; Sokolov, Maxim N.; Babak, Maria V.; Gushchin, Artem L.

In: Inorganic Chemistry, Vol. 61, No. 4, 31.01.2022, p. 2105–2118.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review