Heterogeneous multi-compartmental DNA hydrogel particles prepared via microfluidic assembly for lymphocyte-inspired precision medicine

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Sophie Wan Mei Lian
  • Song Guo
  • Kewei Ren
  • John S. Ho

Related Research Unit(s)

Detail(s)

Original languageEnglish
Pages (from-to)20531-20540
Journal / PublicationNanoscale
Volume13
Issue number48
Online published19 Nov 2021
Publication statusPublished - 28 Dec 2021

Abstract

Lymphocytes play a vital role in immunosurveillance through sensing biomolecules and eliminating targeted invaders. Compared with conventional therapies that depend on drug loading, lymphocytes are advantageous as they are able to ensure self-regulated therapeutics. Here, novel multi-compartmental DNA hydrogel particles were synthesized using a microfluidic assembly for intelligent cancer treatment via the logic-based control of siRNA release without external stimulation. The sensing sequence (D1) was compartmentalized from the treatment sequence (D2) with the use of core-shell DNA hydrogel particles. When D1 detects a cancer-associated biomarker, miRNA-21, a sequence cascade is triggered to release siRNA from D2, effectively eliminating the targeted cancer cells via lymphocyte-inspired precision medicine.

Citation Format(s)

Heterogeneous multi-compartmental DNA hydrogel particles prepared via microfluidic assembly for lymphocyte-inspired precision medicine. / Lian, Sophie Wan Mei; Guo, Song; Ren, Kewei; Xu, Ying; Ho, John S.; Chen, Chia-Hung.

In: Nanoscale, Vol. 13, No. 48, 28.12.2021, p. 20531-20540.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review