Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

11 Scopus Citations
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Author(s)

  • Wei Wang
  • Hongyi Yang
  • Haiyang Tong
  • Lulu Wang
  • Feng Liu
  • Hongsong Chen
  • Kai Zhong
  • Ye Liu
  • Xingyu Jiang

Detail(s)

Original languageEnglish
Pages (from-to)5647-5659
Journal / PublicationACS Nano
Volume16
Issue number4
Online published21 Mar 2022
Publication statusPublished - 26 Apr 2022
Externally publishedYes

Abstract

Challenges remain in precisely diagnosing the progress of liver fibrosis in a noninvasive way. We here synthesized small (4 nm) heterogeneous iron oxide/dysprosium oxide nanoparticles (IO-DyO NPs) as a contrast agent (CA) for magnetic resonance imaging (MRI) to precisely diagnose liver fibrosis in vivo at both 7.0 and 9.4 T field strength. Our IO-DyO NPs can target the liver and show an increased T2 relaxivity along with an increase of magnetic field strength. At a ultrahigh magnetic field, IO-DyO NPs can significantly improve spatial/temporal image resolution and signal-to-noise ratio of the liver and precisely distinguish the early and moderate liver fibrosis stages. Our IO-DyO NP-based MRI diagnosis can exactly match biopsy (a gold standard for liver fibrosis diagnosis in the clinic) but avoid the invasiveness of biopsy. Moreover, our IO-DyO NPs show satisfactory biosafety in vitro and in vivo. This work illustrates an advanced T2 CA used in ultrahigh-field MRI (UHFMRI) for the precise diagnosis of liver fibrosis via a noninvasive means. © 2022 American Chemical Society.

Research Area(s)

  • iron oxide-dysprosium oxide nanoparticles, liver fibrosis, MRI contrast agent, noninvasive detection, ultrahigh-field MRI

Citation Format(s)

Heterogeneous Iron Oxide/Dysprosium Oxide Nanoparticles Target Liver for Precise Magnetic Resonance Imaging of Liver Fibrosis. / Balachandran, Yekkuni L.; Wang, Wei; Yang, Hongyi et al.
In: ACS Nano, Vol. 16, No. 4, 26.04.2022, p. 5647-5659.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review