TY - JOUR
T1 - Heartworm adulticide treatment
T2 - a tropical perspective
AU - Dantas-Torres, Filipe
AU - Ketzis, Jennifer
AU - Pérez Tort, Gabriela
AU - Mihalca, Andrei Daniel
AU - Baneth, Gad
AU - Otranto, Domenico
AU - Watanabe, Malaika
AU - Linh, Bui Khanh
AU - Inpankaew, Tawin
AU - Borrás, Pablo
AU - Arumugam, Sangaran
AU - Penzhorn, Barend Louis
AU - Ybañez, Adrian Patalinghug
AU - Irwin, Peter
AU - Traub, Rebecca J.
PY - 2023
Y1 - 2023
N2 - Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).
AB - Dirofilaria immitis (the canine heartworm) is widespread in the tropics, with prevalence surpassing 30% in high-risk areas. In addition to the suitable climatic conditions that favour mosquito abundance and filarial larva development, there is low compliance with the recommended year-round use of preventives in these transmission hotspots. This represents a major concern, considering that melarsomine (first-line heartworm adulticide) is unavailable in several tropical countries, resulting in the so-called slow-kill protocol being the only available adulticide treatment option. In this article, the members of TroCCAP (Tropical Council for Companion Animal Parasites) review the current distribution of heartworm in the tropics and the availability of melarsomine, and discuss alternatives for the management of heartworm infections in dogs. Graphical Abstract: [Figure not available: see fulltext.] © 2023, The Author(s).
KW - Dirofilaria immitis
KW - Doxycycline
KW - Ivermectin
KW - Melarsomine
KW - Mosquitoes
KW - Moxidectin
KW - One health
KW - Prevention
UR - http://www.scopus.com/inward/record.url?scp=85156210900&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85156210900&origin=recordpage
U2 - 10.1186/s13071-023-05690-8
DO - 10.1186/s13071-023-05690-8
M3 - RGC 21 - Publication in refereed journal
C2 - 37106364
SN - 1756-3305
VL - 16
JO - Parasites and Vectors
JF - Parasites and Vectors
M1 - 148
ER -