Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Man Ka So
  • Nobuyoshi Yamashita
  • Sachi Taniyasu
  • Qinting Jiang
  • John P. Giesy
  • And 2 others
  • Kun Chen
  • Paul Kwan Sing Lam

Detail(s)

Original languageEnglish
Pages (from-to)2924-2929
Journal / PublicationEnvironmental Science and Technology
Volume40
Issue number9
Publication statusPublished - 1 May 2006

Abstract

Recent studies have reported the ubiquitous distribution of perfluorinated compounds (PFCs), especially perfluorooctanesulfonate (PFOS) and perfluorooctanoic acid (PFOA), in wildlife and human whole blood or serum. In 2003 a solid phase extraction method was developed, which allowed the measurement of PFCs in human breast milk. In the present study, PFCs in samples of human breast milk from 19 individuals from Zhoushan, China, were analyzed by modifying a previously established method, based on weak-anion exchange extraction. PFOS and PFOA were the two dominant chemicals detected in all the milk samples. Concentrations of PFOS and PFOA ranged from 45 to 360 ng/L and 47 to 210 ng/L, respectively. The maximum concentrations of other PFCs were 100 ng/L for perfluorohexanesulfonate (PFHxS), 62 ng/L for perfluorononanoate (PFNA), 15 ng/L for perfluorodecanoate (PFDA) and 56 ng/L for perfluoroundecanoate (PFUnDA). Statistically significant correlations between various PFCs suggested a common exposure source to humans. No statistically significant correlation was found between concentrations of either PFOS or PFOA and maternal age, weight, or infant weight. Rate of consumption of fish was found to be positively correlated with PFNA, PFDA, and PFUnDA concentrations. Daily intake of PFOS for the child via breast milk with greater PFOS concentrations exceeded the predicted conservative reference dose in 1 of 19 samples, indicating that there may be a small potential risk of PFOS for the infants in Zhoushan via the consumption of breast milk. © 2006 American Chemical Society.

Citation Format(s)

Health risks in infants associated with exposure to perfluorinated compounds in human breast milk from Zhoushan, China. / So, Man Ka; Yamashita, Nobuyoshi; Taniyasu, Sachi; Jiang, Qinting; Giesy, John P.; Chen, Kun; Lam, Paul Kwan Sing.

In: Environmental Science and Technology, Vol. 40, No. 9, 01.05.2006, p. 2924-2929.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review