Health-related quality of life in pregnancy with uterine fibroid: A cross-sectional study in China

Wai-Kit Ming; Huailiang Wu; Yanxin Wu; Hanqing Chen; Tian Meng; Yiwei Shen; Ziyu Wang; Xinyu Huang; Weiwei Sun; Tik Sang Chow; Yuan Wang; Wenjing DIng; Haitian Chen; Zhuyu Li; Zilian Wang

doi:10.1186/s12955-019-1153-6

Health-related quality of life in pregnancy with uterine fibroid: A cross-sectional study in China

Wai-Kit Ming^*, Huailiang Wu, Yanxin Wu, Hanqing Chen, Tian Meng, Yiwei Shen, Ziyu Wang, Xinyu Huang, Weiwei Sun, Tik Sang Chow, Yuan Wang, Wenjing DIng, Haitian Chen, Zhuyu Li, Zilian Wang

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

15 Citations (Scopus)

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Abstract

Background: Uterine fibroids (UFs) are the most common benign tumors in women. They are likely to cause numerous clinical symptoms, such as pain, menorrhagia, and other obstetric complications in pregnant women. This study aimed to determine the health-related quality of life (HRQoL) during pregnancy with uterine fibroids (UF), thus providing a utility-based case value in pregnant women with UF and understanding of whether HRQoL is associated with clinical outcomes in pregnant women with UFs. Method: This study was conducted in a cross-sectional manner. This study was based on questionnaire surveys completed by sequential out- and in-patients and was conducted in a regional university hospital in Guangzhou, China. The EuroQoL five-dimension-five-level (EQ-5D-5 L) questionnaire was used, and demographic data were collected. An electronic record of the clinical outcomes of pregnant women with UF was retrieved from the hospital's electronic medical record system. The association between UF and HRQoL was evaluated by ordered regression. Results: Seven-hundred-sixty-seven pregnant women with a mean age (SD) of 32.7 (4.8) years completed 707 questionnaires. Overall, when comparing the UF with non-UF groups, we detected statistical differences in age, body mass index (BMI), gravidity and abortion times, partner's smoking and alcoholic habits, advanced maternal age, and uterine scars (p < 0.05). Furthermore, pregnant women without UF scored significantly higher than those with UF on the EQ-5D value system (0.84 versus 0.79; p = 0.017). Moreover, pregnant women with UF suffered more health-related problems, especially with respect to self-care (odds ratio [OR] = 3.69, p < 0.01) and usual activity dimensions (OR = 2.11; p = 0.01). Conclusion: We found that UF has a negative impact on the HRQoL of pregnant women with respect to self-care and usual activity dimensions. Also, the EQ-5D score was a better index than the EQ-VAS score for HRQoL when evaluating of the QoL of our population of pregnant women.

Original language	English
Article number	89
Journal	Health and Quality of Life Outcomes
Volume	17
Issue number	1
DOIs	https://doi.org/10.1186/s12955-019-1153-6
Publication status	Published - 24 May 2019
Externally published	Yes

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title = "Health-related quality of life in pregnancy with uterine fibroid: A cross-sectional study in China",

abstract = "Background: Uterine fibroids (UFs) are the most common benign tumors in women. They are likely to cause numerous clinical symptoms, such as pain, menorrhagia, and other obstetric complications in pregnant women. This study aimed to determine the health-related quality of life (HRQoL) during pregnancy with uterine fibroids (UF), thus providing a utility-based case value in pregnant women with UF and understanding of whether HRQoL is associated with clinical outcomes in pregnant women with UFs. Method: This study was conducted in a cross-sectional manner. This study was based on questionnaire surveys completed by sequential out- and in-patients and was conducted in a regional university hospital in Guangzhou, China. The EuroQoL five-dimension-five-level (EQ-5D-5 L) questionnaire was used, and demographic data were collected. An electronic record of the clinical outcomes of pregnant women with UF was retrieved from the hospital's electronic medical record system. The association between UF and HRQoL was evaluated by ordered regression. Results: Seven-hundred-sixty-seven pregnant women with a mean age (SD) of 32.7 (4.8) years completed 707 questionnaires. Overall, when comparing the UF with non-UF groups, we detected statistical differences in age, body mass index (BMI), gravidity and abortion times, partner's smoking and alcoholic habits, advanced maternal age, and uterine scars (p < 0.05). Furthermore, pregnant women without UF scored significantly higher than those with UF on the EQ-5D value system (0.84 versus 0.79; p = 0.017). Moreover, pregnant women with UF suffered more health-related problems, especially with respect to self-care (odds ratio [OR] = 3.69, p < 0.01) and usual activity dimensions (OR = 2.11; p = 0.01). Conclusion: We found that UF has a negative impact on the HRQoL of pregnant women with respect to self-care and usual activity dimensions. Also, the EQ-5D score was a better index than the EQ-VAS score for HRQoL when evaluating of the QoL of our population of pregnant women.",

author = "Wai-Kit Ming and Huailiang Wu and Yanxin Wu and Hanqing Chen and Tian Meng and Yiwei Shen and Ziyu Wang and Xinyu Huang and Weiwei Sun and Chow, {Tik Sang} and Yuan Wang and Wenjing DIng and Haitian Chen and Zhuyu Li and Zilian Wang",

note = "Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected]. ",

year = "2019",

month = may,

day = "24",

doi = "10.1186/s12955-019-1153-6",

language = "English",

volume = "17",

journal = "Health and Quality of Life Outcomes",

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TY - JOUR

T1 - Health-related quality of life in pregnancy with uterine fibroid

T2 - A cross-sectional study in China

AU - Ming, Wai-Kit

AU - Wu, Huailiang

AU - Wu, Yanxin

AU - Chen, Hanqing

AU - Meng, Tian

AU - Shen, Yiwei

AU - Wang, Ziyu

AU - Huang, Xinyu

AU - Sun, Weiwei

AU - Chow, Tik Sang

AU - Wang, Yuan

AU - DIng, Wenjing

AU - Chen, Haitian

AU - Li, Zhuyu

AU - Wang, Zilian

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2019/5/24

Y1 - 2019/5/24

N2 - Background: Uterine fibroids (UFs) are the most common benign tumors in women. They are likely to cause numerous clinical symptoms, such as pain, menorrhagia, and other obstetric complications in pregnant women. This study aimed to determine the health-related quality of life (HRQoL) during pregnancy with uterine fibroids (UF), thus providing a utility-based case value in pregnant women with UF and understanding of whether HRQoL is associated with clinical outcomes in pregnant women with UFs. Method: This study was conducted in a cross-sectional manner. This study was based on questionnaire surveys completed by sequential out- and in-patients and was conducted in a regional university hospital in Guangzhou, China. The EuroQoL five-dimension-five-level (EQ-5D-5 L) questionnaire was used, and demographic data were collected. An electronic record of the clinical outcomes of pregnant women with UF was retrieved from the hospital's electronic medical record system. The association between UF and HRQoL was evaluated by ordered regression. Results: Seven-hundred-sixty-seven pregnant women with a mean age (SD) of 32.7 (4.8) years completed 707 questionnaires. Overall, when comparing the UF with non-UF groups, we detected statistical differences in age, body mass index (BMI), gravidity and abortion times, partner's smoking and alcoholic habits, advanced maternal age, and uterine scars (p < 0.05). Furthermore, pregnant women without UF scored significantly higher than those with UF on the EQ-5D value system (0.84 versus 0.79; p = 0.017). Moreover, pregnant women with UF suffered more health-related problems, especially with respect to self-care (odds ratio [OR] = 3.69, p < 0.01) and usual activity dimensions (OR = 2.11; p = 0.01). Conclusion: We found that UF has a negative impact on the HRQoL of pregnant women with respect to self-care and usual activity dimensions. Also, the EQ-5D score was a better index than the EQ-VAS score for HRQoL when evaluating of the QoL of our population of pregnant women.

AB - Background: Uterine fibroids (UFs) are the most common benign tumors in women. They are likely to cause numerous clinical symptoms, such as pain, menorrhagia, and other obstetric complications in pregnant women. This study aimed to determine the health-related quality of life (HRQoL) during pregnancy with uterine fibroids (UF), thus providing a utility-based case value in pregnant women with UF and understanding of whether HRQoL is associated with clinical outcomes in pregnant women with UFs. Method: This study was conducted in a cross-sectional manner. This study was based on questionnaire surveys completed by sequential out- and in-patients and was conducted in a regional university hospital in Guangzhou, China. The EuroQoL five-dimension-five-level (EQ-5D-5 L) questionnaire was used, and demographic data were collected. An electronic record of the clinical outcomes of pregnant women with UF was retrieved from the hospital's electronic medical record system. The association between UF and HRQoL was evaluated by ordered regression. Results: Seven-hundred-sixty-seven pregnant women with a mean age (SD) of 32.7 (4.8) years completed 707 questionnaires. Overall, when comparing the UF with non-UF groups, we detected statistical differences in age, body mass index (BMI), gravidity and abortion times, partner's smoking and alcoholic habits, advanced maternal age, and uterine scars (p < 0.05). Furthermore, pregnant women without UF scored significantly higher than those with UF on the EQ-5D value system (0.84 versus 0.79; p = 0.017). Moreover, pregnant women with UF suffered more health-related problems, especially with respect to self-care (odds ratio [OR] = 3.69, p < 0.01) and usual activity dimensions (OR = 2.11; p = 0.01). Conclusion: We found that UF has a negative impact on the HRQoL of pregnant women with respect to self-care and usual activity dimensions. Also, the EQ-5D score was a better index than the EQ-VAS score for HRQoL when evaluating of the QoL of our population of pregnant women.

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U2 - 10.1186/s12955-019-1153-6

DO - 10.1186/s12955-019-1153-6

M3 - RGC 21 - Publication in refereed journal

C2 - 31126289

SN - 1477-7525

VL - 17

JO - Health and Quality of Life Outcomes

JF - Health and Quality of Life Outcomes

IS - 1

M1 - 89

ER -

Health-related quality of life in pregnancy with uterine fibroid: A cross-sectional study in China

Abstract

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