Harvesting the promise of AOPs : An assessment and recommendations

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

30 Scopus Citations
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Author(s)

  • Annamaria Carusi
  • Mark R. Davies
  • Giovanni De Grandis
  • Beate I. Escher
  • Geoff Hodges
  • Maurice Whelan
  • Catherine Willett
  • Gerald T. Ankley

Detail(s)

Original languageEnglish
Pages (from-to)1542-1556
Journal / PublicationScience of the Total Environment
Volume628-629
Online published22 Feb 2018
Publication statusPublished - 1 Jul 2018
Externally publishedYes

Abstract

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. In this paper we identify and describe those stakeholders who currently—or in the future—could benefit from the application of the AOP framework and knowledge to specific problems. We also summarize the challenges faced in implementing pathway-based approaches such as the AOP framework in biological sciences, and provide a series of recommendations to meet critical needs to ensure further progression of the framework as a useful, sustainable and dependable tool supporting assessments of both human health and the environment. Although the AOP concept has the potential to significantly impact the organization and interpretation of biological information in a variety of disciplines/applications, this promise can only be fully realized through the active engagement of, and input from multiple stakeholders, requiring multi-pronged substantive long-term planning and strategies.

Research Area(s)

  • Adverse outcomes pathways, Chemical management, Environmental health, Risk assessment, Social, ethical and legal aspects, Toxicology

Citation Format(s)

Harvesting the promise of AOPs : An assessment and recommendations. / Carusi, Annamaria; Davies, Mark R.; De Grandis, Giovanni; Escher, Beate I.; Hodges, Geoff; Leung, Kenneth M.Y.; Whelan, Maurice; Willett, Catherine; Ankley, Gerald T.

In: Science of the Total Environment, Vol. 628-629, 01.07.2018, p. 1542-1556.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review