Handheld optical-resolution photoacoustic microscopy

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

59 Scopus Citations
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Author(s)

  • Li Lin
  • Pengfei Zhang
  • Song Xu
  • Junhui Shi
  • Lei Li
  • Junjie Yao
  • Jun Zou
  • Lihong V. Wang

Detail(s)

Original languageEnglish
Article number41002
Journal / PublicationJournal of Biomedical Optics
Volume22
Issue number4
Online published24 Oct 2016
Publication statusPublished - Apr 2017

Abstract

Optical-resolution photoacoustic microscopy (OR-PAM) offers label-free in vivo imaging with high spatial resolution by acoustically detecting optical absorption contrasts via the photoacoustic effect. We developed a compact handheld OR-PAM probe for fast photoacoustic imaging. Different from benchtop microscopes, the handheld probe provides flexibility in imaging various anatomical sites. Resembling a cup in size, the probe uses a two-axis water-immersible microelectromechanical system mirror to scan both the illuminating optical beam and resultant acoustic beam. The system performance was tested in vivo by imaging the capillary bed in a mouse ear and both the capillary bed and a mole on a human volunteer.

Research Area(s)

  • confocal scanning, human skin imaging, optical-resolution photoacoustic microscopy, photoacoustic handheld probe, two-axis microelectromechanical system mirror

Citation Format(s)

Handheld optical-resolution photoacoustic microscopy. / Lin, Li; Zhang, Pengfei; Xu, Song et al.
In: Journal of Biomedical Optics, Vol. 22, No. 4, 41002, 04.2017.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review