Habitual physical activity, renal function and chronic kidney disease: A cohort study of nearly 200 000 adults

Cui Guo; Tony Tam; Yacong Bo; Ly-yun Chang; Xiang Qian Lao; G Neil Thomas

doi:10.1136/bjsports-2019-100989

Habitual physical activity, renal function and chronic kidney disease: A cohort study of nearly 200 000 adults

Cui Guo
, Tony Tam
, Yacong Bo
, Ly-yun Chang
, Xiang Qian Lao^*
, G Neil Thomas

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

68 Citations (Scopus)

Abstract

Background There is limited information on the association between habitual physical activity (PA) and renal function.

Objective To report the longitudinal association between self-reported habitual PA and measures of renal function in a large cohort in Taiwan.

Methods A total of 199 421 participants (aged ≥20 years) were selected from a Taiwan cohort between 1996 and 2014. All participants underwent at least two standardised medical examinations between 1996 and 2014. Self-administrated questionnaires were used to collect information on habitual PA. We used a generalised linear mixed model to investigate the associations between habitual PA and yearly change in estimated glomerular filtration rate (eGFR). The Cox proportional hazard regression model was used to investigate the associations between habitual PA and incident chronic kidney disease (CKD).

Results Participants had a median follow-up duration of 4.2 years (0.2-18.9). The yearly mean (±SD) decrease in eGFR in participants with baseline very low-PA, low-PA, moderate-PA and high-PA was 0.46±1.01, 0.36±0.97, 0.30±0.94 and 0.27±0.91 mL/min/1.73 m², respectively. Relative to the participants with very low-PA, the coefficients of yearly eGFR change were -43.93 (95% CI -79.18 to -8.68), 35.20 (95% CI -2.56 to 72.96) and 53.56 (95% CI 10.42 to 96.70) μL/min/1.73 m², respectively, for the participants with low-PA, moderate-PA and high-PA, after controlling for a wide range of covariates. Relative to the very low-PA participants, those who had low-PA, moderate-PA and high-habitual PA had HRs of 0.93 (95% CI 0.88 to 0.98), 0.94 (95% CI 0.89 to 0.99) and 0.91 (95% CI 0.85 to 0.96) to develop CKD, respectively, after controlling for the covariates.

Conclusions A higher level of habitual PA is associated with a smaller decrease in the level of eGFR and a lower risk of developing CKD.

Original language	English
Pages (from-to)	1225-1230
Number of pages	6
Journal	British Journal of Sports Medicine
Volume	54
Issue number	20
Online published	22 Jan 2020
DOIs	https://doi.org/10.1136/bjsports-2019-100989
Publication status	Published - Oct 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
©

Funding

Contributors XQL and GNT conceived and designed the study. LC, TT and XQL acquired the data. CG and YB searched the literature. CG cleaned and analysed the data. CG, TT, XQL and GNT interpreted the results. CG and XQL drafted the manuscript. XQL, CG, GNT, YB, TT and LC revised the manuscript. All authors contributed to the content and critical revision of the manuscript and approved the final version. XQL obtained the funding. XQL is the guarantor of this study. Funding This work was supported in part by the Environmental Health Research Fund of the Chinese University of Hong Kong (7104946). Competing interests None declared. Patient consent for publication Not required. ethics approval Approved by the Joint Chinese University of Hong Kong – New Territories East Cluster Clinical Research Ethics Committee. Acknowledgements The authors appreciate the MJ Health Research Foundation for authorising the use of its health data (authorisation code: MJHR2015002A). Any interpretation or conclusion related to this article does not represent the views of MJ Health Research Foundation. Cui Guo and Yacong Bo are supported by PhD Studentships of the Chinese University of Hong Kong. The authors are grateful to the anonymous reviewers and the journal editors for their valuable comments.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

chronic
exercises
kidney
physical activity

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@article{b41eb3bd5c584e75ad3d34af08d437ed,

title = "Habitual physical activity, renal function and chronic kidney disease: A cohort study of nearly 200 000 adults",

abstract = "Background There is limited information on the association between habitual physical activity (PA) and renal function. Objective To report the longitudinal association between self-reported habitual PA and measures of renal function in a large cohort in Taiwan. Methods A total of 199 421 participants (aged ≥20 years) were selected from a Taiwan cohort between 1996 and 2014. All participants underwent at least two standardised medical examinations between 1996 and 2014. Self-administrated questionnaires were used to collect information on habitual PA. We used a generalised linear mixed model to investigate the associations between habitual PA and yearly change in estimated glomerular filtration rate (eGFR). The Cox proportional hazard regression model was used to investigate the associations between habitual PA and incident chronic kidney disease (CKD). Results Participants had a median follow-up duration of 4.2 years (0.2-18.9). The yearly mean (±SD) decrease in eGFR in participants with baseline very low-PA, low-PA, moderate-PA and high-PA was 0.46±1.01, 0.36±0.97, 0.30±0.94 and 0.27±0.91 mL/min/1.73 m2, respectively. Relative to the participants with very low-PA, the coefficients of yearly eGFR change were -43.93 (95\% CI -79.18 to -8.68), 35.20 (95\% CI -2.56 to 72.96) and 53.56 (95\% CI 10.42 to 96.70) μL/min/1.73 m2, respectively, for the participants with low-PA, moderate-PA and high-PA, after controlling for a wide range of covariates. Relative to the very low-PA participants, those who had low-PA, moderate-PA and high-habitual PA had HRs of 0.93 (95\% CI 0.88 to 0.98), 0.94 (95\% CI 0.89 to 0.99) and 0.91 (95\% CI 0.85 to 0.96) to develop CKD, respectively, after controlling for the covariates. Conclusions A higher level of habitual PA is associated with a smaller decrease in the level of eGFR and a lower risk of developing CKD.",

keywords = "chronic, exercises, kidney, physical activity",

author = "Cui Guo and Tony Tam and Yacong Bo and Ly-yun Chang and Lao, \{Xiang Qian\} and Thomas, \{G Neil\}",

note = "Publisher Copyright: {\textcopyright} ",

year = "2020",

month = oct,

doi = "10.1136/bjsports-2019-100989",

language = "English",

volume = "54",

pages = "1225--1230",

journal = "British Journal of Sports Medicine",

issn = "0306-3674",

publisher = "BMJ Publishing Group Ltd.",

number = "20",

}

TY - JOUR

T1 - Habitual physical activity, renal function and chronic kidney disease

T2 - A cohort study of nearly 200 000 adults

AU - Guo, Cui

AU - Tam, Tony

AU - Bo, Yacong

AU - Chang, Ly-yun

AU - Lao, Xiang Qian

AU - Thomas, G Neil

PY - 2020/10

Y1 - 2020/10

N2 - Background There is limited information on the association between habitual physical activity (PA) and renal function. Objective To report the longitudinal association between self-reported habitual PA and measures of renal function in a large cohort in Taiwan. Methods A total of 199 421 participants (aged ≥20 years) were selected from a Taiwan cohort between 1996 and 2014. All participants underwent at least two standardised medical examinations between 1996 and 2014. Self-administrated questionnaires were used to collect information on habitual PA. We used a generalised linear mixed model to investigate the associations between habitual PA and yearly change in estimated glomerular filtration rate (eGFR). The Cox proportional hazard regression model was used to investigate the associations between habitual PA and incident chronic kidney disease (CKD). Results Participants had a median follow-up duration of 4.2 years (0.2-18.9). The yearly mean (±SD) decrease in eGFR in participants with baseline very low-PA, low-PA, moderate-PA and high-PA was 0.46±1.01, 0.36±0.97, 0.30±0.94 and 0.27±0.91 mL/min/1.73 m2, respectively. Relative to the participants with very low-PA, the coefficients of yearly eGFR change were -43.93 (95% CI -79.18 to -8.68), 35.20 (95% CI -2.56 to 72.96) and 53.56 (95% CI 10.42 to 96.70) μL/min/1.73 m2, respectively, for the participants with low-PA, moderate-PA and high-PA, after controlling for a wide range of covariates. Relative to the very low-PA participants, those who had low-PA, moderate-PA and high-habitual PA had HRs of 0.93 (95% CI 0.88 to 0.98), 0.94 (95% CI 0.89 to 0.99) and 0.91 (95% CI 0.85 to 0.96) to develop CKD, respectively, after controlling for the covariates. Conclusions A higher level of habitual PA is associated with a smaller decrease in the level of eGFR and a lower risk of developing CKD.

AB - Background There is limited information on the association between habitual physical activity (PA) and renal function. Objective To report the longitudinal association between self-reported habitual PA and measures of renal function in a large cohort in Taiwan. Methods A total of 199 421 participants (aged ≥20 years) were selected from a Taiwan cohort between 1996 and 2014. All participants underwent at least two standardised medical examinations between 1996 and 2014. Self-administrated questionnaires were used to collect information on habitual PA. We used a generalised linear mixed model to investigate the associations between habitual PA and yearly change in estimated glomerular filtration rate (eGFR). The Cox proportional hazard regression model was used to investigate the associations between habitual PA and incident chronic kidney disease (CKD). Results Participants had a median follow-up duration of 4.2 years (0.2-18.9). The yearly mean (±SD) decrease in eGFR in participants with baseline very low-PA, low-PA, moderate-PA and high-PA was 0.46±1.01, 0.36±0.97, 0.30±0.94 and 0.27±0.91 mL/min/1.73 m2, respectively. Relative to the participants with very low-PA, the coefficients of yearly eGFR change were -43.93 (95% CI -79.18 to -8.68), 35.20 (95% CI -2.56 to 72.96) and 53.56 (95% CI 10.42 to 96.70) μL/min/1.73 m2, respectively, for the participants with low-PA, moderate-PA and high-PA, after controlling for a wide range of covariates. Relative to the very low-PA participants, those who had low-PA, moderate-PA and high-habitual PA had HRs of 0.93 (95% CI 0.88 to 0.98), 0.94 (95% CI 0.89 to 0.99) and 0.91 (95% CI 0.85 to 0.96) to develop CKD, respectively, after controlling for the covariates. Conclusions A higher level of habitual PA is associated with a smaller decrease in the level of eGFR and a lower risk of developing CKD.

KW - chronic

KW - exercises

KW - kidney

KW - physical activity

UR - https://www.scopus.com/pages/publications/85078429635

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85078429635&origin=recordpage

U2 - 10.1136/bjsports-2019-100989

DO - 10.1136/bjsports-2019-100989

M3 - RGC 21 - Publication in refereed journal

C2 - 31969348

AN - SCOPUS:85078429635

SN - 0306-3674

VL - 54

SP - 1225

EP - 1230

JO - British Journal of Sports Medicine

JF - British Journal of Sports Medicine

IS - 20

ER -

Habitual physical activity, renal function and chronic kidney disease: A cohort study of nearly 200 000 adults

Abstract

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Funding

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Research Keywords

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