TY - JOUR
T1 - Greedy method for inferring tandem duplication history
AU - Zhang, Louxin
AU - Ma, Bin
AU - Wang, Lusheng
AU - Xu, Ying
PY - 2003/8/12
Y1 - 2003/8/12
N2 - Motivation: Genome analysis suggests that tandem duplication is an important mode of evolutionary novelty by permitting one copy of each gene to drift and potentially to acquire a new function. With more and more genomic sequences available, reconstructing duplication history has received extensive attention recently. Results: An efficient method is presented for inferring the duplication history of tandemly repeated sequences based on the model proposed by Fitch (1977). We validate the method by using simulation results and real data sets of mucin genes, ZNF genes, and olfactory receptors genes. The agreement with conclusions drawn by other biological researchers strongly indicates that our method is efficient and robust.
AB - Motivation: Genome analysis suggests that tandem duplication is an important mode of evolutionary novelty by permitting one copy of each gene to drift and potentially to acquire a new function. With more and more genomic sequences available, reconstructing duplication history has received extensive attention recently. Results: An efficient method is presented for inferring the duplication history of tandemly repeated sequences based on the model proposed by Fitch (1977). We validate the method by using simulation results and real data sets of mucin genes, ZNF genes, and olfactory receptors genes. The agreement with conclusions drawn by other biological researchers strongly indicates that our method is efficient and robust.
UR - http://www.scopus.com/inward/record.url?scp=0041886965&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-0041886965&origin=recordpage
U2 - 10.1093/bioinformatics/btg191
DO - 10.1093/bioinformatics/btg191
M3 - RGC 21 - Publication in refereed journal
C2 - 12912830
SN - 1367-4803
VL - 19
SP - 1497
EP - 1504
JO - Bioinformatics
JF - Bioinformatics
IS - 12
ER -