Graphene based pipette tip solid phase extraction of marine toxins in shellfish muscle followed by UPLC-MS/MS analysis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Qing Shen
  • Like Gong
  • Wei Dong
  • Yixuan Wang
  • Zhiyuan Dai
  • Hon-Yeung Cheung

Detail(s)

Original languageEnglish
Pages (from-to)770-775
Journal / PublicationTalanta
Volume116
Online published26 Jul 2013
Publication statusPublished - 15 Nov 2013

Abstract

Graphene is a novel carbonic material with great potentials for the use as sorbent due to its ultrahigh surface area. Herein, we report the use of graphene as sorbent in solid-phase extraction (SPE) using pipette tip as cartridge namely GPT-SPE, together with ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), for the analysis of lipophilic marine toxins (LMTs), including yessotoxins (YTX), okadaic acid (OA), dinophysistoxin-1 (DTX1), gymnodimine (GYM), spirolides-1 (SPX1), pectenotoxin-2 (PTX2) and azaspiracid-1 (AZA1) in shellfish. The GPT-SPE procedure was optimized and the performance of graphene was fully validated. Results with high-sensitivity and good reproducibility was obtained and compared with that of other sorbents like C18 silica, multi-walled carbon nanotubes (MWCNTs), commercial Oasis HLB, and Strata-X for the extraction of LMTs, which showed superiority and advantages of graphene, such as good recoveries, stability and compatibility with various solvents. In order to exhibit the potentials of graphene as an excellent sorbent material, 67 mussel samples from six coastal cities of China were analyzed. OA was found to be the dominant contaminant, while YTX was also detected with low level. © 2013 Elsevier B.V.

Research Area(s)

  • Graphene, LC-MS/MS, Marine toxins, Pipette tip solid-phase extraction, Shellfish

Citation Format(s)

Graphene based pipette tip solid phase extraction of marine toxins in shellfish muscle followed by UPLC-MS/MS analysis. / Shen, Qing; Gong, Like; Baibado, Joewel T.; Dong, Wei; Wang, Yixuan; Dai, Zhiyuan; Cheung, Hon-Yeung.

In: Talanta, Vol. 116, 15.11.2013, p. 770-775.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review