Grape seed extract improves small intestinal health through suppressing inflammation and regulating alkaline phosphatase in IL-10-deficient mice

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

22 Scopus Citations
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Original languageEnglish
Pages (from-to)245-252
Journal / PublicationJournal of Functional Foods
Publication statusPublished - 1 Jan 2016
Externally publishedYes


The effects of dietary grape seed extract (GSE) on protecting jejunum epithelial were investigated using interlukin-10-deficient mice. GSE supplementation increased villus length, mucosal thickness and enhanced goblet cell density associated with enhanced expression of villin and two key differentiation transcription factors, Hairy/Enhancer of Split 1 (Hes1) and Krüppel-Like Factor-4 (Klf4), and increased p21 (CIP1/WAF1) content. Additionally, expression of nutrient transporters, alanyl aminopeptidase and glucose transporter-2 were increased in GSE supplemented jejunum. Consistent with its anti-inflammatory effects, GSE supplementation decreased tumor necrosis factor-α and interferon-γ expression and down-regulated NF-κB signalling. Furthermore, GSE decreased total alkaline phosphatase activity with a concomitant increase in intestinal alkaline phosphatase protein. Thus, GSE improves jejunum health in interlukin10-deficient mice likely through suppressing inflammation and regulating alkaline phosphatase.

Research Area(s)

  • Alkaline phosphatase, Differentiation, GSE, IL-10-deficient mice, Inflammation, Jejunum

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