G-Quadruplexes : Prediction, Characterization, and Biological Application

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

163 Scopus Citations
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Detail(s)

Original languageEnglish
Pages (from-to)997-1013
Journal / PublicationTrends in Biotechnology
Volume35
Issue number10
Online published26 Jul 2017
Publication statusPublished - Oct 2017

Abstract

Guanine (G)-rich sequences in nucleic acids can assemble into G-quadruplex structures that involve G-quartets linked by loop nucleotides. The structural and topological diversity of G-quadruplexes have attracted great attention for decades. Recent methodological advances have advanced the identification and characterization of G-quadruplexes in vivo as well as in vitro, and at a much higher resolution and throughput, which has greatly expanded our current understanding of G-quadruplex structure and function. Accumulating knowledge about the structural properties of G-quadruplexes has helped to design and develop a repertoire of molecular and chemical tools for biological applications. This review highlights how these exciting methods and findings have opened new doors to investigate the potential functions and applications of G-quadruplexes in basic and applied biosciences.

Research Area(s)

  • aptamer, biosensing, cell imaging, G-quadruplex, next-generation sequencing, nucleic acid structure