Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Ching Tung Lum
  • Xiong Liu
  • Raymond Wai-Yin Sun
  • Xiang-Ping Li
  • Ying Peng
  • Hsiang Fu Kung
  • Chi-Ming Che
  • Marie C.M. Lin

Detail(s)

Original languageEnglish
Pages (from-to)159-166
Journal / PublicationCancer Letters
Volume294
Issue number2
Publication statusPublished - Aug 2010
Externally publishedYes

Abstract

A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.

Research Area(s)

  • Cell migration, Gold(III) porphyrin 1a, Invasion, Metastasis, Nasopharyngeal carcinoma (NPC)

Citation Format(s)

Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro. / Lum, Ching Tung; Liu, Xiong; Sun, Raymond Wai-Yin; Li, Xiang-Ping; Peng, Ying; He, Ming-Liang; Kung, Hsiang Fu; Che, Chi-Ming; Lin, Marie C.M.

In: Cancer Letters, Vol. 294, No. 2, 08.2010, p. 159-166.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review