Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

Ching Tung Lum; Xiong Liu; Raymond Wai-Yin Sun; Xiang-Ping Li; Ying Peng; Ming-Liang He; Hsiang Fu Kung; Chi-Ming Che; Marie C.M. Lin

doi:10.1016/j.canlet.2010.01.033

Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

Ching Tung Lum
, Xiong Liu
, Raymond Wai-Yin Sun
, Xiang-Ping Li
, Ying Peng
, Ming-Liang He
, Hsiang Fu Kung
, Chi-Ming Che
, Marie C.M. Lin

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

42 Citations (Scopus)

Abstract

A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.

Original language	English
Pages (from-to)	159-166
Journal	Cancer Letters
Volume	294
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2010.01.033
Publication status	Published - Aug 2010
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

Cell migration
Gold(III) porphyrin 1a
Invasion
Metastasis
Nasopharyngeal carcinoma (NPC)

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10.1016/j.canlet.2010.01.033

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@article{4674f57ce26341c2b7c0a091dd79694c,

title = "Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro",

abstract = "A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. {\textcopyright} 2010 Elsevier Ireland Ltd.",

keywords = "Cell migration, Gold(III) porphyrin 1a, Invasion, Metastasis, Nasopharyngeal carcinoma (NPC)",

author = "Lum, \{Ching Tung\} and Xiong Liu and Sun, \{Raymond Wai-Yin\} and Xiang-Ping Li and Ying Peng and Ming-Liang He and Kung, \{Hsiang Fu\} and Chi-Ming Che and Lin, \{Marie C.M.\}",

year = "2010",

month = aug,

doi = "10.1016/j.canlet.2010.01.033",

language = "English",

volume = "294",

pages = "159--166",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

AU - Lum, Ching Tung

AU - Liu, Xiong

AU - Sun, Raymond Wai-Yin

AU - Li, Xiang-Ping

AU - Peng, Ying

AU - He, Ming-Liang

AU - Kung, Hsiang Fu

AU - Che, Chi-Ming

AU - Lin, Marie C.M.

PY - 2010/8

Y1 - 2010/8

N2 - A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.

AB - A physiologically stable gold compound, gold(III) meso-tetraphenylporphyrin (gold-1a), has been shown to be effective in inducing apoptosis and prolonging the survival of hepatocellular carcinoma (HCC)-bearing rats as well as inhibiting the tumor growth of mice bearing nasopharyngeal carcinoma (NPC), neuroblastoma and colon carcinoma. In this study, we showed that gold-1a prolonged the survival of NPC metastasis-bearing mice and inhibited intrahepatic and lung metastasis. Histologically, gold-1a markedly reduced tumor microvessel formation. Consistently, in in vitro studies, gold-1a inhibited migration and invasion of C666-1 human NPC cells. The data strongly support the use of gold(III) compounds to treat cancer metastasis. © 2010 Elsevier Ireland Ltd.

KW - Cell migration

KW - Gold(III) porphyrin 1a

KW - Invasion

KW - Metastasis

KW - Nasopharyngeal carcinoma (NPC)

UR - https://www.scopus.com/pages/publications/77953363272

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-77953363272&origin=recordpage

U2 - 10.1016/j.canlet.2010.01.033

DO - 10.1016/j.canlet.2010.01.033

M3 - RGC 21 - Publication in refereed journal

C2 - 20163914

SN - 0304-3835

VL - 294

SP - 159

EP - 166

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Gold(III) porphyrin 1a inhibited nasopharyngeal carcinoma metastasis in vivo and inhibited cell migration and invasion in vitro

Abstract

UN SDGs

Research Keywords

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