Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

Xuandi Lai; Xinran Geng; Mengqing Li; Mengxiong Tang; Qiong Liu; Mengsu Yang; Lin Shen; Yu Zhu; Shubin Wang

doi:10.2217/nnm-2021-0100

Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

Xuandi Lai
, Xinran Geng
, Mengqing Li
, Mengxiong Tang
, Qiong Liu
, Mengsu Yang
, Lin Shen
, Yu Zhu
, Shubin Wang^*

^*Corresponding author for this work

Department of Biomedical Sciences

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

7 Citations (Scopus)

Abstract

Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal efficiency was studied in vitro and in vivo. Results: The DCNPs exhibited a rapid drug release profile under high GSH concentration and could enhance the cellular uptake and cytotoxicity of doxorubicin to MDR cancer cells. Moreover, the DCNPs showed better biocompatibility, longer blood circulation and enhanced antitumor efficiency compared with free drugs. Conclusion: The GSH-responsive nanocarrier is believed to be a promising candidate for overcoming tumor MDR.

Original language	English
Pages (from-to)	1411–1427
Journal	Nanomedicine
Volume	16
Issue number	16
Online published	28 May 2021
DOIs	https://doi.org/10.2217/nnm-2021-0100
Publication status	Published - Jul 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Keywords

cancer therapy
drug delivery
GSH response
multidrug resistance
PLGA nanoparticles
GOLD NANOPARTICLES
DRUG-RESISTANCE
REDOX
MICELLES
NANOCARRIERS
RELEASE

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title = "Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance",

abstract = "Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal efficiency was studied in vitro and in vivo. Results: The DCNPs exhibited a rapid drug release profile under high GSH concentration and could enhance the cellular uptake and cytotoxicity of doxorubicin to MDR cancer cells. Moreover, the DCNPs showed better biocompatibility, longer blood circulation and enhanced antitumor efficiency compared with free drugs. Conclusion: The GSH-responsive nanocarrier is believed to be a promising candidate for overcoming tumor MDR.",

keywords = "cancer therapy, drug delivery, GSH response, multidrug resistance, PLGA nanoparticles, GOLD NANOPARTICLES, DRUG-RESISTANCE, REDOX, MICELLES, NANOCARRIERS, RELEASE",

author = "Xuandi Lai and Xinran Geng and Mengqing Li and Mengxiong Tang and Qiong Liu and Mengsu Yang and Lin Shen and Yu Zhu and Shubin Wang",

year = "2021",

month = jul,

doi = "10.2217/nnm-2021-0100",

language = "English",

volume = "16",

pages = "1411–1427",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Taylor \& Francis",

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}

TY - JOUR

T1 - Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

AU - Lai, Xuandi

AU - Geng, Xinran

AU - Li, Mengqing

AU - Tang, Mengxiong

AU - Liu, Qiong

AU - Yang, Mengsu

AU - Shen, Lin

AU - Zhu, Yu

AU - Wang, Shubin

PY - 2021/7

Y1 - 2021/7

N2 - Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal efficiency was studied in vitro and in vivo. Results: The DCNPs exhibited a rapid drug release profile under high GSH concentration and could enhance the cellular uptake and cytotoxicity of doxorubicin to MDR cancer cells. Moreover, the DCNPs showed better biocompatibility, longer blood circulation and enhanced antitumor efficiency compared with free drugs. Conclusion: The GSH-responsive nanocarrier is believed to be a promising candidate for overcoming tumor MDR.

AB - Aim: This work aims to develop an injectable nano-drug delivery system to overcome tumor multidrug resistance (MDR). Methods: A drug delivery nanoplatform based on PEGylated PLGA with glutathione (GSH) responsivity was constructed for dual delivery of doxorubicin and curcumin (termed DCNP), and its MDR reversal efficiency was studied in vitro and in vivo. Results: The DCNPs exhibited a rapid drug release profile under high GSH concentration and could enhance the cellular uptake and cytotoxicity of doxorubicin to MDR cancer cells. Moreover, the DCNPs showed better biocompatibility, longer blood circulation and enhanced antitumor efficiency compared with free drugs. Conclusion: The GSH-responsive nanocarrier is believed to be a promising candidate for overcoming tumor MDR.

KW - cancer therapy

KW - drug delivery

KW - GSH response

KW - multidrug resistance

KW - PLGA nanoparticles

KW - GOLD NANOPARTICLES

KW - DRUG-RESISTANCE

KW - REDOX

KW - MICELLES

KW - NANOCARRIERS

KW - RELEASE

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UR - https://www.scopus.com/pages/publications/85111787310

U2 - 10.2217/nnm-2021-0100

DO - 10.2217/nnm-2021-0100

M3 - RGC 21 - Publication in refereed journal

SN - 1743-5889

VL - 16

SP - 1411

EP - 1427

JO - Nanomedicine

JF - Nanomedicine

IS - 16

ER -

Glutathione-responsive PLGA nanocomplex for dual delivery of doxorubicin and curcumin to overcome tumor multidrug resistance

Abstract

UN SDGs

Research Keywords

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