Glutamine metabolism in Th17/Treg cell fate : applications in Th17 cell-associated diseases
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Detail(s)
| Original language | English |
|---|---|
| Pages (from-to) | 221-233 |
| Journal / Publication | Science China Life Sciences |
| Volume | 64 |
| Issue number | 2 |
| Online published | 13 Jul 2020 |
| Publication status | Published - Feb 2021 |
| Externally published | Yes |
Link(s)
Abstract
Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate. Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17 Treg cell-associated diseases are provided afterward. This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17 Treg cell differentiation.
Research Area(s)
- glutamine, mTOR, Th17 cells, Treg cells, UDP-GlcNAc
Citation Format(s)
Glutamine metabolism in Th17/Treg cell fate : applications in Th17 cell-associated diseases. / Yang, Guan; Xia, Yaoyao; Ren, Wenkai.
In: Science China Life Sciences, Vol. 64, No. 2, 02.2021, p. 221-233.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
