Global cytokine/chemokine profile identifies potential progression prediction indicators in hand-foot-and-mouth disease patients with Enterovirus A71 infections

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

1 Scopus Citations
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Author(s)

  • Yaqing He
  • Ying Chen
  • Jinquan Cheng
  • Jun Meng
  • Hong Yang
  • Yujie Wang
  • Xiangjie Yao
  • Qianjin Feng
  • Long Chen
  • Hailong Zhang
  • Maggie H.T. Wang
  • Benny C. Y. Zee

Detail(s)

Original languageEnglish
Article number154765
Journal / PublicationCytokine
Volume123
Online published27 Jun 2019
Publication statusPublished - Nov 2019

Abstract

Objective: New clinical indicators are urgently needed for predicting the progression and complications of hand-foot-and-mouth disease (HFMD) caused by EV-A71 infections. 
Materials and Methods: Serum specimens from 132 EV-A71 HFMD patients and 73 health children were collected during 2012 to 2014 in Shenzhen, China. The specific cytokines/chemokines were detected with a 274-human cytokine antibody array, followed by a 38-inflammation cytokine array, and further validated by ELISA.
Results: Cytokines varied in different severity of EV-A71 HFMD patients. The ROC curve analysis revealed 6 serum cytokines with high sensitivity and specificity in predicting the disease progression. Eotaxin, IL-8 and IP-10 have showed high AUC values (0.90 - 0.95) for discrimination between the health controls and the patient group. The three cytokines showed high sensitivity (80% - 91%) and specificity (88% - 95%). MMP-8 had a high sensitivity and specificity to predict mild HFMD (100%, 100%). IL-1b and leptin discriminated the severe/critical group from the mild group (79% and 69% in sensitivity, 73% and 63% in specificity). 
Conclusions: Eotaxin, IP-10 and IL-8 could be potential indicators for predicting HFMD progression with EV-A71 infection. MMP-8 is a specific indicator for mild infection, while IL-1b and leptin display potential for predicting the severity and criticality.

Research Area(s)

  • Cytokine/chemokine array, EV-A71, Hand-foot-and-mouth disease, Indicator, Inflammation profile

Citation Format(s)

Global cytokine/chemokine profile identifies potential progression prediction indicators in hand-foot-and-mouth disease patients with Enterovirus A71 infections. / He, Yaqing; Feng, Zhuoying; Wang, Wei; Chen, Ying; Cheng, Jinquan; Meng, Jun; Yang, Hong; Wang, Yujie; Yao, Xiangjie; Feng, Qianjin; Chen, Long; Zhang, Hailong; Wang, Maggie H.T.; Zee, Benny C. Y.; Wang, Xin; HE, Mingliang.

In: Cytokine, Vol. 123, 154765, 11.2019.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal