TY - JOUR
T1 - Global burden, risk factors, and trends of esophageal cancer
T2 - An analysis of cancer registries from 48 countries
AU - Huang, Junjie
AU - Koulaouzidis, Anastasios
AU - Marlicz, Wojciech
AU - Lok, Veeleah
AU - Chu, Cedric
AU - Ngai, Chun Ho
AU - Zhang, Lin
AU - Chen, Ping
AU - Wang, Shanjuan
AU - Yuan, Jinqiu
AU - Lao, Xiang-Qian
AU - Tse, Shelly L.A.
AU - Xu, Wanghong
AU - Zheng, Zhi-Jie
AU - Xie, Shao-Hua
AU - Wong, Martin C.S.
N1 - Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/1
Y1 - 2021/1
N2 - This study aimed to examine the global burden, risk factors, and trends of esophageal cancer based on age, sex, and histological subtype. The data were retrieved from cancer registries database from 48 countries in the period 1980–2017. Temporal patterns of incidence and mortality were evaluated by average annual percent change (AAPC) using joinpoint regression. Associations with risk factors were examined by linear regression. The highest incidence of esophageal cancer was observed in Eastern Asia. The highest incidence of adenocarcinoma (AC) was found in the Netherlands, the United Kingdom, and Ireland. A higher AC/squamous cell carcinoma (SCC) incidence ratio was associated with a higher prevalence of obesity and elevated cholesterol. We observed an incidence increase (including AC and SCC) in some countries, with the Czech Republic (female: AAPC 4.66), Spain (female: 3.41), Norway (male: 3.10), Japan (female: 2.18), Thailand (male: 2.17), the Netherlands (male: 2.11; female: 1.88), and Canada (male: 1.51) showing the most significant increase. Countries with increasing mortality included Thailand (male: 5.24), Austria (female: 3.67), Latvia (male: 2.33), and Portugal (male: 1.12). Although the incidence of esophageal cancer showed an overall decreasing trend, an increasing trend was observed in some countries with high AC/SCC incidence ratios. More preventive measures are needed for these countries.
AB - This study aimed to examine the global burden, risk factors, and trends of esophageal cancer based on age, sex, and histological subtype. The data were retrieved from cancer registries database from 48 countries in the period 1980–2017. Temporal patterns of incidence and mortality were evaluated by average annual percent change (AAPC) using joinpoint regression. Associations with risk factors were examined by linear regression. The highest incidence of esophageal cancer was observed in Eastern Asia. The highest incidence of adenocarcinoma (AC) was found in the Netherlands, the United Kingdom, and Ireland. A higher AC/squamous cell carcinoma (SCC) incidence ratio was associated with a higher prevalence of obesity and elevated cholesterol. We observed an incidence increase (including AC and SCC) in some countries, with the Czech Republic (female: AAPC 4.66), Spain (female: 3.41), Norway (male: 3.10), Japan (female: 2.18), Thailand (male: 2.17), the Netherlands (male: 2.11; female: 1.88), and Canada (male: 1.51) showing the most significant increase. Countries with increasing mortality included Thailand (male: 5.24), Austria (female: 3.67), Latvia (male: 2.33), and Portugal (male: 1.12). Although the incidence of esophageal cancer showed an overall decreasing trend, an increasing trend was observed in some countries with high AC/SCC incidence ratios. More preventive measures are needed for these countries.
KW - Esophageal cancer
KW - Histological subtypes
KW - Incidence
KW - Mortality
KW - Risk factors
UR - http://www.scopus.com/inward/record.url?scp=85099865225&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85099865225&origin=recordpage
U2 - 10.3390/cancers13010141
DO - 10.3390/cancers13010141
M3 - RGC 21 - Publication in refereed journal
C2 - 33466239
AN - SCOPUS:85099865225
SN - 2072-6694
VL - 13
JO - Cancers
JF - Cancers
IS - 1
M1 - 141
ER -
