Global burden, risk factors, and trends of esophageal cancer: An analysis of cancer registries from 48 countries

Junjie Huang, Anastasios Koulaouzidis, Wojciech Marlicz, Veeleah Lok, Cedric Chu, Chun Ho Ngai, Lin Zhang, Ping Chen, Shanjuan Wang, Jinqiu Yuan, Xiang-Qian Lao, Shelly L.A. Tse, Wanghong Xu, Zhi-Jie Zheng, Shao-Hua Xie, Martin C.S. Wong*

*Corresponding author for this work

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

153 Citations (Scopus)
36 Downloads (CityUHK Scholars)

Abstract

This study aimed to examine the global burden, risk factors, and trends of esophageal cancer based on age, sex, and histological subtype. The data were retrieved from cancer registries database from 48 countries in the period 1980–2017. Temporal patterns of incidence and mortality were evaluated by average annual percent change (AAPC) using joinpoint regression. Associations with risk factors were examined by linear regression. The highest incidence of esophageal cancer was observed in Eastern Asia. The highest incidence of adenocarcinoma (AC) was found in the Netherlands, the United Kingdom, and Ireland. A higher AC/squamous cell carcinoma (SCC) incidence ratio was associated with a higher prevalence of obesity and elevated cholesterol. We observed an incidence increase (including AC and SCC) in some countries, with the Czech Republic (female: AAPC 4.66), Spain (female: 3.41), Norway (male: 3.10), Japan (female: 2.18), Thailand (male: 2.17), the Netherlands (male: 2.11; female: 1.88), and Canada (male: 1.51) showing the most significant increase. Countries with increasing mortality included Thailand (male: 5.24), Austria (female: 3.67), Latvia (male: 2.33), and Portugal (male: 1.12). Although the incidence of esophageal cancer showed an overall decreasing trend, an increasing trend was observed in some countries with high AC/SCC incidence ratios. More preventive measures are needed for these countries.
Original languageEnglish
Article number141
Number of pages16
JournalCancers
Volume13
Issue number1
Online published5 Jan 2021
DOIs
Publication statusPublished - Jan 2021
Externally publishedYes

Research Keywords

  • Esophageal cancer
  • Histological subtypes
  • Incidence
  • Mortality
  • Risk factors

Publisher's Copyright Statement

  • This full text is made available under CC-BY 4.0. https://creativecommons.org/licenses/by/4.0/

Fingerprint

Dive into the research topics of 'Global burden, risk factors, and trends of esophageal cancer: An analysis of cancer registries from 48 countries'. Together they form a unique fingerprint.

Cite this