Global analysis of protein function using protein microarrays

Michael G. Smith; Ghil Jona; Jason Ptacek; Geeta Devgan; Heng Zhu; Xiaowei Zhu; Michael Snyder

doi:10.1016/j.mad.2004.09.019

Global analysis of protein function using protein microarrays

Michael G. Smith
, Ghil Jona
, Jason Ptacek
, Geeta Devgan
, Heng Zhu
, Xiaowei Zhu
, Michael Snyder

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

33 Citations (Scopus)

Abstract

Protein microarrays containing thousands of proteins arrayed at high density can be prepared and probed for a wide variety of activities, thereby allowing the large scale analysis of many proteins simultaneously. In addition to identifying the activities of many previously uncharacterized proteins, protein microarrays can reveal new activities of well-characterized proteins, thus providing new insights about the functions of these proteins. Below, we describe the construction and use of protein microarrays and their applications using yeast as a model system. © 2004 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Pages (from-to)	171-175
Journal	Mechanisms of Ageing and Development
Volume	126
Issue number	1
DOIs	https://doi.org/10.1016/j.mad.2004.09.019
Publication status	Published - Jan 2005
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Research Keywords

Discovery research
Genome
High-throughput
Microarrays
Proteomics

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10.1016/j.mad.2004.09.019

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abstract = "Protein microarrays containing thousands of proteins arrayed at high density can be prepared and probed for a wide variety of activities, thereby allowing the large scale analysis of many proteins simultaneously. In addition to identifying the activities of many previously uncharacterized proteins, protein microarrays can reveal new activities of well-characterized proteins, thus providing new insights about the functions of these proteins. Below, we describe the construction and use of protein microarrays and their applications using yeast as a model system. {\textcopyright} 2004 Elsevier Ireland Ltd. All rights reserved.",

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T1 - Global analysis of protein function using protein microarrays

AU - Smith, Michael G.

AU - Jona, Ghil

AU - Ptacek, Jason

AU - Devgan, Geeta

AU - Zhu, Heng

AU - Zhu, Xiaowei

AU - Snyder, Michael

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2005/1

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N2 - Protein microarrays containing thousands of proteins arrayed at high density can be prepared and probed for a wide variety of activities, thereby allowing the large scale analysis of many proteins simultaneously. In addition to identifying the activities of many previously uncharacterized proteins, protein microarrays can reveal new activities of well-characterized proteins, thus providing new insights about the functions of these proteins. Below, we describe the construction and use of protein microarrays and their applications using yeast as a model system. © 2004 Elsevier Ireland Ltd. All rights reserved.

AB - Protein microarrays containing thousands of proteins arrayed at high density can be prepared and probed for a wide variety of activities, thereby allowing the large scale analysis of many proteins simultaneously. In addition to identifying the activities of many previously uncharacterized proteins, protein microarrays can reveal new activities of well-characterized proteins, thus providing new insights about the functions of these proteins. Below, we describe the construction and use of protein microarrays and their applications using yeast as a model system. © 2004 Elsevier Ireland Ltd. All rights reserved.

KW - Discovery research

KW - Genome

KW - High-throughput

KW - Microarrays

KW - Proteomics

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DO - 10.1016/j.mad.2004.09.019

M3 - RGC 21 - Publication in refereed journal

C2 - 15610776

SN - 0047-6374

VL - 126

SP - 171

EP - 175

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

IS - 1

ER -

Global analysis of protein function using protein microarrays

Abstract

Bibliographical note

Research Keywords

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