Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiaoyun Shen
  • P. K S Lam
  • G. R. Shaw
  • W. Wickramasinghe

Detail(s)

Original languageEnglish
Pages (from-to)1499-1501
Journal / PublicationToxicon
Volume40
Issue number10
Publication statusPublished - 1 Oct 2002

Abstract

Cylindrospermopsin (CYN), a potent cyanobacterial hepatotoxin produced by Cylindrospermopsis raciborskii and other cyanobacteria, is regularly found in water supplies in many parts of the world, and has been associated with the intoxication of humans and livestock. In this study, Balb/c mice were injected via the intraperitoneal (IP) route with a single dose of 0.2mg/kg CYN. Animals were sacrificed at 6, 12, 24, 48 and 72h. DNA was isolated from the mouse livers, and examined for strand breakage by alkaline gel electrophoresis (pH 12). Significant DNA strand breakage was observed in the mouse liver exposed to CYN, suggesting that induction of DNA strand breakage is probably one of the key mechanisms for CYN genotoxicity. © 2002 Elsevier Science Ltd. All rights reserved.

Research Area(s)

  • Alkaline gel electrophoresis, Cylindrospermopsin, DNA strand breaks, Genotoxicity

Citation Format(s)

Genotoxicity investigation of a cyanobacterial toxin, cylindrospermopsin. / Shen, Xiaoyun; Lam, P. K S; Shaw, G. R.; Wickramasinghe, W.

In: Toxicon, Vol. 40, No. 10, 01.10.2002, p. 1499-1501.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review