Abstract
Heterologous expression of a cryptic gene cluster in the fungus Aspergillus funiculosus CBS 116.56 led to the discovery of four new meroterpenoids, funiculolides A–D (1–4), derived from the aromatic polyketide 5-methylorsellinic acid (5-MOA). Intriguingly, funiculolide D (4), the apparent end product of the pathway, harbors an unusual spirocyclopentanone moiety, which is synthesized by the oxidative rearrangement catalyzed by the ferrous iron and α-ketoglutarate-dependent dioxygenase FncG.
| Original language | English |
|---|---|
| Pages (from-to) | 3211-3215 |
| Number of pages | 5 |
| Journal | Organic Letters |
| Volume | 23 |
| Issue number | 8 |
| Online published | 6 Apr 2021 |
| DOIs | |
| Publication status | Published - 16 Apr 2021 |
Publisher's Copyright Statement
- COPYRIGHT TERMS OF DEPOSITED POSTPRINT FILE: This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of the Organic Letters, copyright © 2021 American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.1c00951.