Genetic variation in a4GnT in relation to helicobacter pylori serology and gastric cancer risk

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review

8 Scopus Citations
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Author(s)

  • Yanbin Jia
  • Lifang Hou
  • Christina Persson
  • Meredith Yeager
  • Jolanta Lissowska
  • Stephen J. Chanock
  • Martin Blaser
  • Wong-Ho Chow
  • Weimin Ye

Detail(s)

Original languageEnglish
Pages (from-to)120-125
Journal / PublicationHelicobacter
Volume14
Issue number5
Publication statusPublished - Oct 2009
Externally publishedYes

Abstract

Background: Helicobacter pylori, a known risk factor of gastric cancer, rarely colonize the deeper portion of normal gastric glands, where the mucus is rich in α-1,4-linked N-acetylglucosamine capped O-glycans, that strongly inhibit H. pylori growth in vitro. Materials and methods: We investigated the association between genetic variation in the O-glycan transferase encoding gene (a4GnT) and H. pylori infection and gastric cancer risk using a Polish population-based case-control study (273 gastric cancer patients and 377 controls). Results: A haplotype at the rs2622694-rs397266 locus was associated with H. pylori infection, with the A-A haplotype associated with a higher risk compared with the most frequent G-G haplotype (odds ratio 2.30; 95% confidence interval 1.35-3.92). The association remained significant after correction for multiple tests (global p value: nominal 0.002, empirical 0.045). Neither this haplotype nor the tagSNPs were associated with overall gastric cancer risk. Conclusion: a4GnT genetic variation may be relevant to H. pylori infection, but not to gastric cancer risk. © Published 2009. This article is a US Government work and is in the public domain in the USA.

Research Area(s)

  • Gastric cancer, Genetic susceptibility, Helicobacter pylori

Citation Format(s)

Genetic variation in a4GnT in relation to helicobacter pylori serology and gastric cancer risk. / Zheng, Zongli; Jia, Yanbin; Hou, Lifang; Persson, Christina; Yeager, Meredith; Lissowska, Jolanta; Chanock, Stephen J.; Blaser, Martin; Chow, Wong-Ho; Ye, Weimin.

In: Helicobacter, Vol. 14, No. 5, 10.2009, p. 120-125.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalNot applicablepeer-review