Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

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Author(s)

  • Bing-Ying Xu
  • Li-Ping Guo
  • Hong Yao
  • Li-Hua Li
  • Qing-Ming Dong
  • Yi Tan
  • Hsiang-Fu Kung
  • Shui-Shan Lee
  • Che-Kit Lin

Detail(s)

Original languageEnglish
Pages (from-to)2100-2103
Journal / PublicationWorld Journal of Gastroenterology
Volume13
Issue number14
Publication statusPublished - 14 Apr 2007
Externally publishedYes

Abstract

Aim: To investigate the genotype and allelic frequencies of Cytochrome P450 2B6 polymorphisms in four southern Chinese populations. Methods: DNA was obtained from blood samples from Han Chinese from Hong Kong and three minority groups, the Wa, Bulang and Lahu from Yunnan in southern China. Genotyping was performed using real-time PCR and confirmed by direct sequencing. Results: A total of 507 subjects from southern China were studied. Results showed there is a high prevalence of 516G > T (34.5%) in ethnic Chinese compared to literature reports on other Asian populations and Caucasians. The frequency of the 516TT genotype is higher in the Han majority (23.1%) than in three other ethnic minority groups (i.e., 7.4%, 9.1% and 15.8%) in southern China. Conclusion: This was the first study to document the spectrum of CYP2B6 allelic variants and genotypes in a southern Chinese population. The 516G > T allele is associated with a defective metabolism of efavirenz (EFV), which therefore may predispose to drug toxicity. Treatment regimens for human immunodeficiency virus (HIV) and heroin addiction may need to be optimized in different populations because of the marked variability of the key metabolizing enzyme. © 2007 The WJG Press. All rights reserved.

Research Area(s)

  • Allele, Discrimination PCR, Ethnicity, Genotype, Polymorphism

Citation Format(s)

Genetic variability of CYP2B6 polymorphisms in four southern Chinese populations. / Xu, Bing-Ying; Guo, Li-Ping; Yao, Hong; Li, Li-Hua; Dong, Qing-Ming; Tan, Yi; Kung, Hsiang-Fu; He, Ming-Liang; Lee, Shui-Shan; Lin, Che-Kit.

In: World Journal of Gastroenterology, Vol. 13, No. 14, 14.04.2007, p. 2100-2103.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal