Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal

8 Scopus Citations
View graph of relations

Author(s)

  • Jiachang Cai
  • Qipeng Cheng
  • Yingbo Shen
  • Danxia Gu
  • Ying Fang
  • Edward Wai-Chi Chan

Detail(s)

Original languageEnglish
Article numbere00562-17
Journal / PublicationAntimicrobial Agents and Chemotherapy
Volume61
Issue number7
Online published8 May 2017
Publication statusPublished - Jul 2017
Externally publishedYes

Abstract

We report the genetic and functional characterization of a novel CTX-M-199 β-lactamase, which was encoded by a blaCTX-M-64 variant gene found in a conjugative mcr-1-bearing IncI2 plasmid and exhibited resistance to β-lactamase inhibitors, tazobactam, and sulbactam.

Research Area(s)

  • Conjugative IncI2 plasmid, CTX-M-199, Enzyme kinetics, Function, Inhibitor resistance, mcr-1

Citation Format(s)

Genetic and Functional Characterization of blaCTX-M-199, a Novel Tazobactam and Sulbactam Resistance-Encoding Gene Located in a Conjugative mcr-1-Bearing IncI2 Plasmid. / Cai, Jiachang; Cheng, Qipeng; Shen, Yingbo; Gu, Danxia; Fang, Ying; Chan, Edward Wai-Chi; Chen, Sheng.

In: Antimicrobial Agents and Chemotherapy, Vol. 61, No. 7, e00562-17, 07.2017.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journal