TY - JOUR
T1 - Gene expression profiles showing hepatotoxicity in Balb/c mice exposed to cyclophosphamide and ifosfamide
AU - Gao, Li-Hong
AU - Ao, Ling
AU - Hu, Ran
AU - Liu, Jin-Yi
AU - Huang, Ming-Hui
AU - Yang, Meng-Su
AU - Cao, Jia
PY - 2006/4
Y1 - 2006/4
N2 - AIM: To study the molecular mechanism of hepatotoxicity of cyclophosphamide and ifosfamide. METHODS: Utilizing toxicological microarray and animal model of cyclophosphamide (CP) and ifosfamide (Ifo) injured Balb/c mouse liver, which established by ourself, to observe the gene expression profiles at different time after drug treatment, and analyze the function of these differential expressed genes by hierarchical clustering and querying bioinformation databases. RESULTS: Multiple differential expressed genes were found. Some similar expression changes existed in gene expression profiles after treatments of two drugs, such as up-regulated protein synthesis associated genes, unbalanced anti-oxidation associated gene expression, abnormal immunity, cell cycle and apoptosis associated genes suggesting multiple common mechanisms involve hepatotoxicities of CP and Ifo. CONCLUSION: There are common molecular mechanisms in hepatotoxicity of CP and Ifo.
AB - AIM: To study the molecular mechanism of hepatotoxicity of cyclophosphamide and ifosfamide. METHODS: Utilizing toxicological microarray and animal model of cyclophosphamide (CP) and ifosfamide (Ifo) injured Balb/c mouse liver, which established by ourself, to observe the gene expression profiles at different time after drug treatment, and analyze the function of these differential expressed genes by hierarchical clustering and querying bioinformation databases. RESULTS: Multiple differential expressed genes were found. Some similar expression changes existed in gene expression profiles after treatments of two drugs, such as up-regulated protein synthesis associated genes, unbalanced anti-oxidation associated gene expression, abnormal immunity, cell cycle and apoptosis associated genes suggesting multiple common mechanisms involve hepatotoxicities of CP and Ifo. CONCLUSION: There are common molecular mechanisms in hepatotoxicity of CP and Ifo.
KW - Cyclophosphamide
KW - Gene expression profile
KW - Ifosfamide
KW - Liver
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M3 - RGC 21 - Publication in refereed journal
SN - 1000-3002
VL - 20
SP - 138
EP - 143
JO - Chinese Journal of Pharmacology and Toxicology
JF - Chinese Journal of Pharmacology and Toxicology
IS - 2
ER -