Gene expression profile in H4IIE rat hepatoma cells exposed to an antifouling booster biocide Irgarol-1051 degradation product

Yan Xu; Ka-Ho Lam; Lam Michael Hon-Wah

doi:10.3969/j.issn.1003-7985.2014.04.018

Gene expression profile in H4IIE rat hepatoma cells exposed to an antifouling booster biocide Irgarol-1051 degradation product

Yan Xu, Ka-Ho Lam, Lam Michael Hon-Wah

Research output: Journal Publications and Reviews › RGC 22 - Publication in policy or professional journal

Abstract

To better understand the toxicity of an antifouling booster biocide Irgarol-1051 degradation product M2(3-[4-tert-butylamino-6-methylthiol-s-triazin-2-ylamino]pro-pionaldehyde), this study utilized a DNA microarray technique to explore the genotoxicity of M2. The Affymetrix, Inc. rat genome 230 2.0 GeneChip was employed to examine alterations in gene regulation in rat hepatoma cells exposed to 30 μmol/L of M2 for 96 h. The results showed that 38 genes were significantly (p

Original language	English
Pages (from-to)	506-513
Journal	Journal of Southeast University (English Edition)
Volume	30
Issue number	4
DOIs	https://doi.org/10.3969/j.issn.1003-7985.2014.04.018
Publication status	Published - 1 Dec 2014

Research Keywords

Degradation product M2
Gene expression
Genotoxicity
Irgarol-1051
Microarray

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10.3969/j.issn.1003-7985.2014.04.018

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title = "Gene expression profile in H4IIE rat hepatoma cells exposed to an antifouling booster biocide Irgarol-1051 degradation product",

abstract = "To better understand the toxicity of an antifouling booster biocide Irgarol-1051 degradation product M2(3-[4-tert-butylamino-6-methylthiol-s-triazin-2-ylamino]pro-pionaldehyde), this study utilized a DNA microarray technique to explore the genotoxicity of M2. The Affymetrix, Inc. rat genome 230 2.0 GeneChip was employed to examine alterations in gene regulation in rat hepatoma cells exposed to 30 μmol/L of M2 for 96 h. The results showed that 38 genes were significantly (p",

keywords = "Degradation product M2, Gene expression, Genotoxicity, Irgarol-1051, Microarray",

author = "Yan Xu and Ka-Ho Lam and Hon-Wah, {Lam Michael}",

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Gene expression profile in H4IIE rat hepatoma cells exposed to an antifouling booster biocide Irgarol-1051 degradation product. / Xu, Yan; Lam, Ka-Ho; Hon-Wah, Lam Michael.
In: Journal of Southeast University (English Edition), Vol. 30, No. 4, 01.12.2014, p. 506-513.

Research output: Journal Publications and Reviews › RGC 22 - Publication in policy or professional journal

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AU - Xu, Yan

AU - Lam, Ka-Ho

AU - Hon-Wah, Lam Michael

PY - 2014/12/1

Y1 - 2014/12/1

N2 - To better understand the toxicity of an antifouling booster biocide Irgarol-1051 degradation product M2(3-[4-tert-butylamino-6-methylthiol-s-triazin-2-ylamino]pro-pionaldehyde), this study utilized a DNA microarray technique to explore the genotoxicity of M2. The Affymetrix, Inc. rat genome 230 2.0 GeneChip was employed to examine alterations in gene regulation in rat hepatoma cells exposed to 30 μmol/L of M2 for 96 h. The results showed that 38 genes were significantly (p

AB - To better understand the toxicity of an antifouling booster biocide Irgarol-1051 degradation product M2(3-[4-tert-butylamino-6-methylthiol-s-triazin-2-ylamino]pro-pionaldehyde), this study utilized a DNA microarray technique to explore the genotoxicity of M2. The Affymetrix, Inc. rat genome 230 2.0 GeneChip was employed to examine alterations in gene regulation in rat hepatoma cells exposed to 30 μmol/L of M2 for 96 h. The results showed that 38 genes were significantly (p

KW - Degradation product M2

KW - Gene expression

KW - Genotoxicity

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KW - Microarray

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SN - 1003-7985

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JO - Journal of Southeast University (English Edition)

JF - Journal of Southeast University (English Edition)

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Gene expression profile in H4IIE rat hepatoma cells exposed to an antifouling booster biocide Irgarol-1051 degradation product

Abstract

Research Keywords

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