Gas chromatography-mass spectrometry determination of matrine in human plasma

Dan S.T. Sit; Guanghua Gao; Francis C.P. Law; Paul C.H. Li

doi:10.1016/j.jchromb.2004.05.010

Author(s)

Dan S.T. Sit
Guanghua Gao
Francis C.P. Law
Paul C.H. Li

Detail(s)

Original language	English
Pages (from-to)	209-214
Journal / Publication	Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
Volume	808
Issue number	2
Publication status	Published - 5 Sept 2004
Externally published	Yes

Link(s)

DOI	DOI https://doi.org/10.1016/j.jchromb.2004.05.010 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-3242656364&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(4c40abb7-885c-40f9-8b18-374722b8945a).html

Abstract

A method was developed for the quantification of matrine in human plasma using a liquid-liquid extraction procedure followed by gas-chromatography-mass spectrometry (GC/MS) analysis. Deuterated matrine, an internal standard of the analysis, was spiked into the plasma samples before extraction. Linear detection responses were obtained for matrine concentrations ranging from 10 to 500 ng/ml. The intra-day and inter-day precision ranged from 0.4 to 4.0% and 1.0-3.5%, respectively. The intra-day accuracy was between -7.3 and 4.5%. The limit of quantification for matrine was 23 ng/ml. The extraction efficiency averaged about 38%. The validated GC/MS method will be used to quantify matrine in human plasma samples collected in a clinical trial study. © 2004 Elsevier B.V. All rights reserved.

Research Area(s)

Matrine

Bibliographic Note

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Citation Format(s)

[ RIS ] [ BibTeX ]

Gas chromatography-mass spectrometry determination of matrine in human plasma. / Sit, Dan S.T.; Gao, Guanghua; Law, Francis C.P. et al.
In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, Vol. 808, No. 2, 05.09.2004, p. 209-214.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Sit, DST, Gao, G, Law, FCP & Li, PCH 2004, 'Gas chromatography-mass spectrometry determination of matrine in human plasma', Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, vol. 808, no. 2, pp. 209-214. https://doi.org/10.1016/j.jchromb.2004.05.010

Sit, D. S. T., Gao, G., Law, F. C. P., & Li, P. C. H. (2004). Gas chromatography-mass spectrometry determination of matrine in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 808(2), 209-214. https://doi.org/10.1016/j.jchromb.2004.05.010

Sit DST, Gao G, Law FCP, Li PCH. Gas chromatography-mass spectrometry determination of matrine in human plasma. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2004 Sept 5;808(2):209-214. doi: 10.1016/j.jchromb.2004.05.010

Sit, Dan S.T. ; Gao, Guanghua ; Law, Francis C.P. et al. / Gas chromatography-mass spectrometry determination of matrine in human plasma. In: Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 2004 ; Vol. 808, No. 2. pp. 209-214.