Gallium containing high entropy alloy inhibits biofilm formation and enhances osseointegration

Xinchen Zhu; Junfeng Wang; Yun Du; Jian Zhang; Shubin Wang; Da Shu; Yihao Liu; Fupeng Li; Yixuan Lin; Yiqi Yang; Jiang Ju; Tao Yang; Jian He; Chunjie Liu; Kai Huang; Fengxiang Liu; Wentao Lin; Shengbing Yang

doi:10.1016/j.compositesb.2025.112194

Gallium containing high entropy alloy inhibits biofilm formation and enhances osseointegration

Xinchen Zhu
, Junfeng Wang
, Yun Du
, Jian Zhang
, Shubin Wang
, Da Shu^*
, Yihao Liu
, Fupeng Li
, Yixuan Lin
, Yiqi Yang
, Jiang Ju
, Tao Yang
, Jian He
, Chunjie Liu
, Kai Huang^*
, Fengxiang Liu^*
, Wentao Lin^*
, Shengbing Yang^*

^*Corresponding author for this work

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

4 Citations (Scopus)

Abstract

Prosthetic joint infections have gained tremendous attention in recent years due to their high treatment costs, severe personal consequences, and heavy social burdens. Antimicrobial high-entropy alloys (HEAs) are considered promising implant materials for PJI prevention because of their mechanical properties surpass those of conventional alloys. In this study, we developed a series of gallium (Ga)-containing HEAs and experimentally identified an appropriate addition ratio of Ga. These alloys not only demonstrated excellent mechanical properties and wear resistance but also exhibited strong antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P.a), both common in orthopedic infections. Additionally, Ga-containing HEAs showed good biocompatibility and osteoblastic ability and significant antibacterial therapeutic effects in a dorsal subcutaneous implantation model. In conclusion, Ga-containing HEAs raw materials hold promise as ideal implant materials for orthopedic applications. © 2025 Elsevier Ltd.

Original language	English
Article number	112194
Journal	Composites Part B: Engineering
Volume	295
Online published	31 Jan 2025
DOIs	https://doi.org/10.1016/j.compositesb.2025.112194
Publication status	Published - 15 Apr 2025

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SDG 3 Good Health and Well-being

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Zhu, X., Wang, J., Du, Y., Zhang, J., Wang, S., Shu, D., Liu, Y., Li, F., Lin, Y., Yang, Y., Ju, J., Yang, T., He, J., Liu, C., Huang, K., Liu, F., Lin, W., & Yang, S. (2025). Gallium containing high entropy alloy inhibits biofilm formation and enhances osseointegration. Composites Part B: Engineering, 295, Article 112194. https://doi.org/10.1016/j.compositesb.2025.112194

@article{40100a662cb24766ae662807caeb928f,

title = "Gallium containing high entropy alloy inhibits biofilm formation and enhances osseointegration",

abstract = "Prosthetic joint infections have gained tremendous attention in recent years due to their high treatment costs, severe personal consequences, and heavy social burdens. Antimicrobial high-entropy alloys (HEAs) are considered promising implant materials for PJI prevention because of their mechanical properties surpass those of conventional alloys. In this study, we developed a series of gallium (Ga)-containing HEAs and experimentally identified an appropriate addition ratio of Ga. These alloys not only demonstrated excellent mechanical properties and wear resistance but also exhibited strong antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P.a), both common in orthopedic infections. Additionally, Ga-containing HEAs showed good biocompatibility and osteoblastic ability and significant antibacterial therapeutic effects in a dorsal subcutaneous implantation model. In conclusion, Ga-containing HEAs raw materials hold promise as ideal implant materials for orthopedic applications. {\textcopyright} 2025 Elsevier Ltd.",

author = "Xinchen Zhu and Junfeng Wang and Yun Du and Jian Zhang and Shubin Wang and Da Shu and Yihao Liu and Fupeng Li and Yixuan Lin and Yiqi Yang and Jiang Ju and Tao Yang and Jian He and Chunjie Liu and Kai Huang and Fengxiang Liu and Wentao Lin and Shengbing Yang",

year = "2025",

month = apr,

day = "15",

doi = "10.1016/j.compositesb.2025.112194",

language = "English",

volume = "295",

journal = "Composites Part B: Engineering",

issn = "1359-8368",

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TY - JOUR

T1 - Gallium containing high entropy alloy inhibits biofilm formation and enhances osseointegration

AU - Zhu, Xinchen

AU - Wang, Junfeng

AU - Du, Yun

AU - Zhang, Jian

AU - Wang, Shubin

AU - Shu, Da

AU - Liu, Yihao

AU - Li, Fupeng

AU - Lin, Yixuan

AU - Yang, Yiqi

AU - Ju, Jiang

AU - Yang, Tao

AU - He, Jian

AU - Liu, Chunjie

AU - Huang, Kai

AU - Liu, Fengxiang

AU - Lin, Wentao

AU - Yang, Shengbing

PY - 2025/4/15

Y1 - 2025/4/15

N2 - Prosthetic joint infections have gained tremendous attention in recent years due to their high treatment costs, severe personal consequences, and heavy social burdens. Antimicrobial high-entropy alloys (HEAs) are considered promising implant materials for PJI prevention because of their mechanical properties surpass those of conventional alloys. In this study, we developed a series of gallium (Ga)-containing HEAs and experimentally identified an appropriate addition ratio of Ga. These alloys not only demonstrated excellent mechanical properties and wear resistance but also exhibited strong antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P.a), both common in orthopedic infections. Additionally, Ga-containing HEAs showed good biocompatibility and osteoblastic ability and significant antibacterial therapeutic effects in a dorsal subcutaneous implantation model. In conclusion, Ga-containing HEAs raw materials hold promise as ideal implant materials for orthopedic applications. © 2025 Elsevier Ltd.

AB - Prosthetic joint infections have gained tremendous attention in recent years due to their high treatment costs, severe personal consequences, and heavy social burdens. Antimicrobial high-entropy alloys (HEAs) are considered promising implant materials for PJI prevention because of their mechanical properties surpass those of conventional alloys. In this study, we developed a series of gallium (Ga)-containing HEAs and experimentally identified an appropriate addition ratio of Ga. These alloys not only demonstrated excellent mechanical properties and wear resistance but also exhibited strong antibiofilm activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa (P.a), both common in orthopedic infections. Additionally, Ga-containing HEAs showed good biocompatibility and osteoblastic ability and significant antibacterial therapeutic effects in a dorsal subcutaneous implantation model. In conclusion, Ga-containing HEAs raw materials hold promise as ideal implant materials for orthopedic applications. © 2025 Elsevier Ltd.

UR - https://www.scopus.com/pages/publications/85216924076

UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85216924076&origin=recordpage

U2 - 10.1016/j.compositesb.2025.112194

DO - 10.1016/j.compositesb.2025.112194

M3 - RGC 21 - Publication in refereed journal

SN - 1359-8368

VL - 295

JO - Composites Part B: Engineering

JF - Composites Part B: Engineering

M1 - 112194

ER -

Gallium containing high entropy alloy inhibits biofilm formation and enhances osseointegration

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