Gadolinium-europium carbonate particles: Controlled precipitation for luminescent biolabeling

Séverine Lechevallier; Pierre Lecante; Robert Mauricot; Hervé Dexpert; Jeannette Dexpert-Ghys; Hoi-Kuan Kong; Ga-Lai Law; Ka-Leung Wong

doi:10.1021/cm102134k

Gadolinium-europium carbonate particles: Controlled precipitation for luminescent biolabeling

Séverine Lechevallier, Pierre Lecante, Robert Mauricot, Hervé Dexpert, Jeannette Dexpert-Ghys, Hoi-Kuan Kong, Ga-Lai Law, Ka-Leung Wong

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

78 Citations (Scopus)

Abstract

Europium-doped gadolinium carbonates particles have been prepared via urea-assisted precipitation. The reaction has been followed step by step with the investigations of the precipitate by transmission electron microscopy and wide-angle X-ray scattering, in relation with infrared absorption and thermal analyses. It has been observed that spherical particles of (Gd _0.95Eu_0.05)(OH)CO₃, monodispersed in size and amorphous, precipitate first and then transform to agglomerated platelike crystals of (Gd_0.95Eu_0.05)₂(CO ₃)₃ 2H₂O as the precipitation continues. The Eu³⁺ ⁵D₀→⁷F_J emission spectrum and the ⁵D₀ lifetime in the two carbonate matrices have been measured. Selected hydroxycarbonate nanoparticles (NPs), with diameters of 164 ± 20 nm, have been then transformed to oxide NPs having the cubic crystalline structure C-(Gd_0.95Eu _0.05)₂O₃,with the same shape and size. The photoluminescence (PL) properties of hydroxycarbonate and oxide NPs, and of their colloidal suspensions in water, have been investigated. The hydroxycarbonate and the oxide NPs exhibit same PL intensities when excitation is achieved in one of the Eu³⁺(4f⁶) levels. Tests of in vitro fluorescence imaging have been performed. The luminescent NPs have been observed after their internalization by human cervical carcinoma (HeLa) cells. It is concluded that the controlled (urea-assisted) precipitation is appropriate to synthesize Gd(OH)CO₃:Eu³⁺ and Gd₂O ₃:Eu³⁺ nanoparticles having adequate characteristics for biolabeling. © 2010 American Chemical Society.

Original language	English
Pages (from-to)	6153-6161
Journal	Chemistry of Materials
Volume	22
Issue number	22
DOIs	https://doi.org/10.1021/cm102134k
Publication status	Published - 23 Nov 2010
Externally published	Yes

Bibliographical note

Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

Funding

The authors thank A. Zwick, S. Joulié, and D. Neumeyer (CEMES-CNRS) for their help in handling the luminescence (Micro-Raman), TEM images, and TGA−DTA experiments. Travel expenses were supported by the Hong Kong−France Research Grant (No. 9050206) of the PROCORE program.

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SDG 3 Good Health and Well-being
SDG 13 Climate Action

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title = "Gadolinium-europium carbonate particles: Controlled precipitation for luminescent biolabeling",

abstract = "Europium-doped gadolinium carbonates particles have been prepared via urea-assisted precipitation. The reaction has been followed step by step with the investigations of the precipitate by transmission electron microscopy and wide-angle X-ray scattering, in relation with infrared absorption and thermal analyses. It has been observed that spherical particles of (Gd 0.95Eu0.05)(OH)CO3, monodispersed in size and amorphous, precipitate first and then transform to agglomerated platelike crystals of (Gd0.95Eu0.05)2(CO 3)3 2H2O as the precipitation continues. The Eu3+ 5D0→7FJ emission spectrum and the 5D0 lifetime in the two carbonate matrices have been measured. Selected hydroxycarbonate nanoparticles (NPs), with diameters of 164 ± 20 nm, have been then transformed to oxide NPs having the cubic crystalline structure C-(Gd0.95Eu 0.05)2O3,with the same shape and size. The photoluminescence (PL) properties of hydroxycarbonate and oxide NPs, and of their colloidal suspensions in water, have been investigated. The hydroxycarbonate and the oxide NPs exhibit same PL intensities when excitation is achieved in one of the Eu3+(4f6) levels. Tests of in vitro fluorescence imaging have been performed. The luminescent NPs have been observed after their internalization by human cervical carcinoma (HeLa) cells. It is concluded that the controlled (urea-assisted) precipitation is appropriate to synthesize Gd(OH)CO3:Eu3+ and Gd2O 3:Eu3+ nanoparticles having adequate characteristics for biolabeling. {\textcopyright} 2010 American Chemical Society.",

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T1 - Gadolinium-europium carbonate particles

T2 - Controlled precipitation for luminescent biolabeling

AU - Lechevallier, Séverine

AU - Lecante, Pierre

AU - Mauricot, Robert

AU - Dexpert, Hervé

AU - Dexpert-Ghys, Jeannette

AU - Kong, Hoi-Kuan

AU - Law, Ga-Lai

AU - Wong, Ka-Leung

N1 - Publication details (e.g. title, author(s), publication statuses and dates) are captured on an “AS IS” and “AS AVAILABLE” basis at the time of record harvesting from the data source. Suggestions for further amendments or supplementary information can be sent to [email protected].

PY - 2010/11/23

Y1 - 2010/11/23

N2 - Europium-doped gadolinium carbonates particles have been prepared via urea-assisted precipitation. The reaction has been followed step by step with the investigations of the precipitate by transmission electron microscopy and wide-angle X-ray scattering, in relation with infrared absorption and thermal analyses. It has been observed that spherical particles of (Gd 0.95Eu0.05)(OH)CO3, monodispersed in size and amorphous, precipitate first and then transform to agglomerated platelike crystals of (Gd0.95Eu0.05)2(CO 3)3 2H2O as the precipitation continues. The Eu3+ 5D0→7FJ emission spectrum and the 5D0 lifetime in the two carbonate matrices have been measured. Selected hydroxycarbonate nanoparticles (NPs), with diameters of 164 ± 20 nm, have been then transformed to oxide NPs having the cubic crystalline structure C-(Gd0.95Eu 0.05)2O3,with the same shape and size. The photoluminescence (PL) properties of hydroxycarbonate and oxide NPs, and of their colloidal suspensions in water, have been investigated. The hydroxycarbonate and the oxide NPs exhibit same PL intensities when excitation is achieved in one of the Eu3+(4f6) levels. Tests of in vitro fluorescence imaging have been performed. The luminescent NPs have been observed after their internalization by human cervical carcinoma (HeLa) cells. It is concluded that the controlled (urea-assisted) precipitation is appropriate to synthesize Gd(OH)CO3:Eu3+ and Gd2O 3:Eu3+ nanoparticles having adequate characteristics for biolabeling. © 2010 American Chemical Society.

AB - Europium-doped gadolinium carbonates particles have been prepared via urea-assisted precipitation. The reaction has been followed step by step with the investigations of the precipitate by transmission electron microscopy and wide-angle X-ray scattering, in relation with infrared absorption and thermal analyses. It has been observed that spherical particles of (Gd 0.95Eu0.05)(OH)CO3, monodispersed in size and amorphous, precipitate first and then transform to agglomerated platelike crystals of (Gd0.95Eu0.05)2(CO 3)3 2H2O as the precipitation continues. The Eu3+ 5D0→7FJ emission spectrum and the 5D0 lifetime in the two carbonate matrices have been measured. Selected hydroxycarbonate nanoparticles (NPs), with diameters of 164 ± 20 nm, have been then transformed to oxide NPs having the cubic crystalline structure C-(Gd0.95Eu 0.05)2O3,with the same shape and size. The photoluminescence (PL) properties of hydroxycarbonate and oxide NPs, and of their colloidal suspensions in water, have been investigated. The hydroxycarbonate and the oxide NPs exhibit same PL intensities when excitation is achieved in one of the Eu3+(4f6) levels. Tests of in vitro fluorescence imaging have been performed. The luminescent NPs have been observed after their internalization by human cervical carcinoma (HeLa) cells. It is concluded that the controlled (urea-assisted) precipitation is appropriate to synthesize Gd(OH)CO3:Eu3+ and Gd2O 3:Eu3+ nanoparticles having adequate characteristics for biolabeling. © 2010 American Chemical Society.

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U2 - 10.1021/cm102134k

DO - 10.1021/cm102134k

M3 - RGC 21 - Publication in refereed journal

SN - 0897-4756

VL - 22

SP - 6153

EP - 6161

JO - Chemistry of Materials

JF - Chemistry of Materials

IS - 22

ER -

Gadolinium-europium carbonate particles: Controlled precipitation for luminescent biolabeling

Abstract

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Funding

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