Fungal Meroterpenoids

Yudai Matsuda; Ikuro Abe

doi:10.1016/B978-0-12-409547-2.14663-3

Fungal Meroterpenoids

Department of Chemistry

Research output: Chapters, Conference Papers, Creative and Literary Works › RGC 12 - Chapter in an edited book (Author) › peer-review

Abstract

Meroterpenoids are natural products that are partly derived from a terpenoid pathway, and those obtained from fungi exhibit a wide range of biological activities and structural diversity. The last decade witnessed significant advances in the elucidation of the fungal meroterpenoid pathways, and thus the biosynthetic logics to synthesize the complicated frameworks of meroterpenoids have been disclosed at genetic and enzymological levels. This article will first summarize the general biosynthetic scheme that provides the backbone structures of fungal meroterpenoids, and then discuss several classes of tailoring enzymes that contribute to their structural diversification and complexification.

Original language	English
Title of host publication	Reference Module in Chemistry, Molecular Sciences and Chemical Engineering
Publisher	Elsevier
ISBN (Print)	9780124095472
DOIs	https://doi.org/10.1016/B978-0-12-409547-2.14663-3
Publication status	Published - 2019

Research Keywords

3,5-Dimethyl orsellinic acid
Acetyltransferases
Cytochrome P450 monooxygenases
EpoxidasesFe(II)/α-ketoglutarate-dependent dioxygenases
Flavoenzymes
Indole diterpenoids
Meroterpenoids
Isomerases
Polyketide synthases
Prenyltransferases
Short-chain dehydrogenases/reductases
Terpene cyclases

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10.1016/B978-0-12-409547-2.14663-3

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title = "Fungal Meroterpenoids",

abstract = "Meroterpenoids are natural products that are partly derived from a terpenoid pathway, and those obtained from fungi exhibit a wide range of biological activities and structural diversity. The last decade witnessed significant advances in the elucidation of the fungal meroterpenoid pathways, and thus the biosynthetic logics to synthesize the complicated frameworks of meroterpenoids have been disclosed at genetic and enzymological levels. This article will first summarize the general biosynthetic scheme that provides the backbone structures of fungal meroterpenoids, and then discuss several classes of tailoring enzymes that contribute to their structural diversification and complexification.",

keywords = "3,5-Dimethyl orsellinic acid, Acetyltransferases, Cytochrome P450 monooxygenases, EpoxidasesFe(II)/α-ketoglutarate-dependent dioxygenases, Flavoenzymes, Indole diterpenoids, Meroterpenoids, Isomerases, Polyketide synthases, Prenyltransferases, Short-chain dehydrogenases/reductases, Terpene cyclases",

author = "Yudai Matsuda and Ikuro Abe",

year = "2019",

doi = "10.1016/B978-0-12-409547-2.14663-3",

language = "English",

isbn = "9780124095472",

booktitle = "Reference Module in Chemistry, Molecular Sciences and Chemical Engineering",

publisher = "Elsevier",

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TY - CHAP

T1 - Fungal Meroterpenoids

AU - Matsuda, Yudai

AU - Abe, Ikuro

PY - 2019

Y1 - 2019

N2 - Meroterpenoids are natural products that are partly derived from a terpenoid pathway, and those obtained from fungi exhibit a wide range of biological activities and structural diversity. The last decade witnessed significant advances in the elucidation of the fungal meroterpenoid pathways, and thus the biosynthetic logics to synthesize the complicated frameworks of meroterpenoids have been disclosed at genetic and enzymological levels. This article will first summarize the general biosynthetic scheme that provides the backbone structures of fungal meroterpenoids, and then discuss several classes of tailoring enzymes that contribute to their structural diversification and complexification.

AB - Meroterpenoids are natural products that are partly derived from a terpenoid pathway, and those obtained from fungi exhibit a wide range of biological activities and structural diversity. The last decade witnessed significant advances in the elucidation of the fungal meroterpenoid pathways, and thus the biosynthetic logics to synthesize the complicated frameworks of meroterpenoids have been disclosed at genetic and enzymological levels. This article will first summarize the general biosynthetic scheme that provides the backbone structures of fungal meroterpenoids, and then discuss several classes of tailoring enzymes that contribute to their structural diversification and complexification.

KW - 3,5-Dimethyl orsellinic acid

KW - Acetyltransferases

KW - Cytochrome P450 monooxygenases

KW - EpoxidasesFe(II)/α-ketoglutarate-dependent dioxygenases

KW - Flavoenzymes

KW - Indole diterpenoids

KW - Meroterpenoids

KW - Isomerases

KW - Polyketide synthases

KW - Prenyltransferases

KW - Short-chain dehydrogenases/reductases

KW - Terpene cyclases

U2 - 10.1016/B978-0-12-409547-2.14663-3

DO - 10.1016/B978-0-12-409547-2.14663-3

M3 - RGC 12 - Chapter in an edited book (Author)

SN - 9780124095472

BT - Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

PB - Elsevier

ER -

Fungal Meroterpenoids

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Research Keywords

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