Functionalized europium nanorods for in vitro imaging

Ka-Leung Wong; Ga-Lai Law; Margaret B. Murphy; Peter A. Tanner; Wing-Tak Wong; Paul Kwan-Sing Lam; Michael Hon-Wah Lam

doi:10.1021/ic8000416

Author(s)

Ka-Leung Wong
Ga-Lai Law
Margaret B. Murphy
Peter A. Tanner
Wing-Tak Wong
And 2 others

Paul Kwan-Sing Lam
Michael Hon-Wah Lam

Detail(s)

Original language	English
Pages (from-to)	5190-5196
Journal / Publication	Inorganic Chemistry
Volume	47
Issue number	12
Publication status	Published - 16 Jun 2008

Link(s)

DOI	DOI https://doi.org/10.1021/ic8000416 Final Published version
	Check@CityULib
Link to Scopus	https://www.scopus.com/record/display.uri?eid=2-s2.0-46949090827&origin=recordpage
Permanent Link	https://scholars.cityu.edu.hk/en/publications/publication(ee20fa56-f33e-4fce-bfa9-f513b3d32e1a).html

Abstract

Emissive europium hydroxide nanorods (ENR) (20 nm x 500 nm) functionalized by a surface coating of chromophore-containing organically modified silicate (ORMOSIL) layer, have been synthesized and characterized by high-resolution transmission electron microscopy (TEM). Low-temperature photophysical characterization of the functionalized nanorods (FENR) demonstrated a strong red ⁵D₀ luminescence both in solid and in suspended solutions. Potentials of this nanorod material for live cell imaging have also been explored. Both the bare and functionalized nanorods are able to enter living human cells with no discernible cytotoxicity. Chromophore-to-Eu ³⁺ energy-transfer in the functionalized nanorods enables staining of the cytoplasm of living human cells. This is confirmed by costaining with fluorescent dextran. The red chromophore-sensitized luminescence from the internalized nanorods in live human lung carcinoma cells (A549) can be observed by confocal microscopy 2 h after loading and reaches maximal emission after 24 h. © 2008 American Chemical Society.

Research Area(s)

SDG 3 - Good Health and Well-being

Citation Format(s)

[ RIS ] [ BibTeX ]

Functionalized europium nanorods for in vitro imaging. / Wong, Ka-Leung; Law, Ga-Lai; Murphy, Margaret B. et al.
In: Inorganic Chemistry, Vol. 47, No. 12, 16.06.2008, p. 5190-5196.

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

Wong, K-L, Law, G-L, Murphy, MB, Tanner, PA, Wong, W-T, Lam, PK-S & Lam, MH-W 2008, 'Functionalized europium nanorods for in vitro imaging', Inorganic Chemistry, vol. 47, no. 12, pp. 5190-5196. https://doi.org/10.1021/ic8000416

Wong, K.-L., Law, G.-L., Murphy, M. B., Tanner, P. A., Wong, W.-T., Lam, P. K.-S., & Lam, M. H.-W. (2008). Functionalized europium nanorods for in vitro imaging. Inorganic Chemistry, 47(12), 5190-5196. https://doi.org/10.1021/ic8000416

Wong KL, Law GL, Murphy MB, Tanner PA, Wong WT, Lam PKS et al. Functionalized europium nanorods for in vitro imaging. Inorganic Chemistry. 2008 Jun 16;47(12):5190-5196. doi: 10.1021/ic8000416

Wong, Ka-Leung ; Law, Ga-Lai ; Murphy, Margaret B. et al. / Functionalized europium nanorods for in vitro imaging. In: Inorganic Chemistry. 2008 ; Vol. 47, No. 12. pp. 5190-5196.