Functionalized Cortical Bone-Inspired Composites Adapt to the Mechanical and Biological Properties of the Edentulous Area to Resist Fretting Wear

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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  • ZhongYi Wang
  • QianRong Xiang
  • Xin Tan
  • YaDong Zhang
  • Jian Pu
  • JiKui Sun
  • ManLin Sun
  • YingKai Wang
  • Qiang Wei
  • HaiYang Yu

Related Research Unit(s)


Original languageEnglish
Number of pages15
Journal / PublicationAdvanced Science
Online published12 Feb 2023
Publication statusOnline published - 12 Feb 2023


Dental implants with long-term success of osseointegration have always been the goal, however, difficulties exist. The accumulation of fretting damage at the implant–bone interface often gets overlooked. Commonly used titanium is approximately 7-fold harder and stiffer than cortical bone. Stress shielding caused by the mismatching of the elastic modulus aggravates fretting at the interface, which is accompanied by the risk of the formation of proinflammatory metal debris and implant loosening. Thus, the authors explore functionalized cortical bone-inspired composites (FCBIC) with a hierarchical structure at multiple scales, that exhibit good mechanical and biological adaptivity with cortical bone. The design is inspired by nature, combining brittle minerals with organic molecules to maintain machinability, which helps to acquire excellent energy-dissipating capability. It therefore has the comparable hardness and elastic modulus, strength, and elastic-plastic deformation to cortical bone. Meanwhile, this cortical bone analogy exhibits excellent osteoinduction and osseointegration abilities. These two properties also facilitate each other to resist fretting wear, and therefore improve the success rate of implantation. Based on these results, the biological–mechanical co-operation coefficient is proposed to describe the coupling between these two factors for designing the optimized dental implants. © 2023 The Authors. Advanced Science published by Wiley-VCH GmbH.

Research Area(s)

  • biological–mechanical adaptivity, dentition defects, fretting wear, implant–bone interface, zirconia

Citation Format(s)