Functional organization of the maternal and paternal human 4D Nucleome
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Article number | 103452 |
Journal / Publication | iScience |
Volume | 24 |
Issue number | 12 |
Online published | 16 Nov 2021 |
Publication status | Published - 17 Dec 2021 |
Link(s)
DOI | DOI |
---|---|
Attachment(s) | Documents
Publisher's Copyright Statement
|
Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85119934418&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(183a9e07-9467-4034-9951-e06e7860a9dd).html |
Abstract
Every human somatic cell inherits a maternal and a paternal genome, which work together to give rise to cellular phenotypes. However, the allele-specific relationship between gene expression and genome structure through the cell cycle is largely unknown. By integrating haplotype-resolved genome-wide chromosome conformation capture, mature and nascent mRNA, and protein binding data from a B lymphoblastoid cell line, we investigate this relationship both globally and locally. We introduce the maternal and paternal 4D Nucleome, enabling detailed analysis of the mechanisms and dynamics of genome structure and gene function for diploid organisms. Our analyses find significant coordination between allelic expression biases and local genome conformation, and notably absent expression bias in universally essential cell cycle and glycolysis genes. We propose a model in which coordinated biallelic expression reflects prioritized preservation of essential gene sets.
Research Area(s)
- Bioinformatics, Genomic analysis, Genomics
Citation Format(s)
Functional organization of the maternal and paternal human 4D Nucleome. / Lindsly, Stephen; Jia, Wenlong; Chen, Haiming et al.
In: iScience, Vol. 24, No. 12, 103452, 17.12.2021.
In: iScience, Vol. 24, No. 12, 103452, 17.12.2021.
Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review
Download Statistics
No data available