TY - JOUR
T1 - Functional Imaging with Nucleic-Acid-Based Sensors
T2 - Technology, Application and Future Healthcare Prospects
AU - Wiraja, Christian
AU - Yeo, David C.
AU - Lio, Daniel Chin Shiuan
AU - Zheng, Mengjia
AU - Xu, Chenjie
PY - 2019/2/15
Y1 - 2019/2/15
N2 - Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.
AB - Timely monitoring and assessment of human health plays a crucial role in maintaining the wellbeing of our advancing society. In addition to medical tools and devices, suitable probe agents are crucial to assist such monitoring, either in passive or active ways (i.e., sensors) through inducible signals. In this review we highlight recent developments in activatable optical sensors based on nucleic acids. Sensing mechanisms and bio-applications of these nucleic acid sensors in ex vivo assays, intracellular or in vivo settings are described. In addition, we discuss the limitations of these sensors and how nanotechnology can complement/enhance sensor properties to promote translation into clinical applications.
KW - activatable probes
KW - biosensors
KW - functional imaging
KW - nanotechnology
KW - nucleic acids
UR - http://www.scopus.com/inward/record.url?scp=85056833915&partnerID=8YFLogxK
UR - https://www.scopus.com/record/pubmetrics.uri?eid=2-s2.0-85056833915&origin=recordpage
U2 - 10.1002/cbic.201800430
DO - 10.1002/cbic.201800430
M3 - RGC 21 - Publication in refereed journal
C2 - 30230165
SN - 1439-4227
VL - 20
SP - 437
EP - 450
JO - ChemBioChem
JF - ChemBioChem
IS - 4
ER -