Function of miR-125b in zebrafish neurogenesis

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

1 Scopus Citations
View graph of relations

Author(s)

  • Cathleen Teh
  • Ng Shyh-Chang
  • Vladimir Korzh
  • Harvey F. Lodish
  • Bing Lim

Detail(s)

Original languageEnglish
Pages (from-to)635-640
Journal / PublicationWorld Academy of Science, Engineering and Technology
Volume62
Publication statusPublished - Feb 2010
Externally publishedYes

Abstract

MicroRNAs are an important class of gene expression regulators that are involved in many biological processes including embryogenesis. miR-125b is a conserved microRNA that is enriched in the nervous system. We have previously reported the function of miR-125b in neuronal differentiation of human cell lines. We also discovered the function of miR-125b in regulating p53 in human and zebrafish. Here we further characterize the brain defects in zebrafish embryos injected with morpholinos against miR-125b. Our data confirm the essential role of miR-125b in brain morphogenesis particularly in maintaining the balance between proliferation, cell death and differentiation. We identified lunatic fringe (lfng) as an additional target of miR-125b in human and zebrafish and suggest that lfng may mediate the function of miR-125b in neurogenesis. Together, this report reveals new insights into the function of miR- 125b during neural development of zebrafish.

Research Area(s)

  • MicroRNA, MiR-125b, Neurogenesis, Zebrafish

Citation Format(s)

Function of miR-125b in zebrafish neurogenesis. / Le, Minh T. N.; Teh, Cathleen; Shyh-Chang, Ng; Korzh, Vladimir; Lodish, Harvey F.; Lim, Bing.

In: World Academy of Science, Engineering and Technology, Vol. 62, 02.2010, p. 635-640.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review