Full-Scale Osteochondral Regeneration by Sole Graft of Tissue-Engineered Hyaline Cartilage without Co-Engraftment of Subchondral Bone Substitute

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Xiaolei Nie
  • Jian Yang
  • Yon Jin Chuah
  • Wenzhen Zhu
  • Yvonne Peck
  • Pengfei He

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number1901304
Journal / PublicationAdvanced Healthcare Materials
Volume9
Issue number2
Online published10 Dec 2019
Publication statusPublished - 22 Jan 2020

Abstract

In this study, full-scale osteochondral defects are hypothesized, which penetrate the articular cartilage layer and invade into subchondral bones, and can be fixed by sole graft of tissue-engineered hyaline cartilage without co-engraftment of any subchondral bone substitute. It is hypothesized that given a finely regenerated articular cartilage shielding on top, the restoration of subchondral bones can be fulfilled via spontaneous self-remodeling in situ. Hence, the key challenge of osteochondral regeneration lies in restoration of the non-self-regenerative articular cartilage. Here, traumatic osteochondral lesions to be repaired in rabbit knee models are endeavored using novel tissue-engineered hyaline-like cartilage grafts that are produced by 3D cultured porcine chondrocytes in vitro. Comparative trials are conducted in animal models that are implanted with living hyaline cartilage grafts (LhCG) and decellularized LhCG (dLhCG). Sound osteochondral regeneration is gradually revealed from both LhCG and dLhCG-implanted samples 50–100 d after implantation. Quality regeneration in both zones of articular cartilage and subchondral bones are validated by the restored osteochondral composition, structure, phenotype, and mechanical property, which validate the hypothesis of this study.

Research Area(s)

  • biomaterials, cartilage, decellularization, osteochondral regeneration, tissue engineering

Citation Format(s)

Full-Scale Osteochondral Regeneration by Sole Graft of Tissue-Engineered Hyaline Cartilage without Co-Engraftment of Subchondral Bone Substitute. / Nie, Xiaolei; Yang, Jian; Chuah, Yon Jin; Zhu, Wenzhen; Peck, Yvonne; He, Pengfei; Wang, Dong-An.

In: Advanced Healthcare Materials, Vol. 9, No. 2, 1901304, 22.01.2020.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review