Freshwater crustacean exposed to active pharmaceutical ingredients : ecotoxicological effects and mechanisms

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

5 Scopus Citations
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Author(s)

  • Jiahua Guo
  • Jingya Ren
  • Chao Chang
  • Qiannan Duan
  • Jun Li
  • Mirella Kanerva
  • Fangshe Yang

Detail(s)

Original languageEnglish
Pages (from-to)48868–48902
Journal / PublicationEnvironmental Science and Pollution Research
Volume30
Issue number17
Online published8 Mar 2023
Publication statusPublished - Apr 2023

Abstract

Concerns over the ecotoxicological effects of active pharmaceutical ingredients (APIs) on aquatic invertebrates have been raised in the last decade. While numerous studies have reported the toxicity of APIs in invertebrates, no attempt has been made to synthesize and interpret this dataset in terms of different exposure scenarios (acute, chronic, multigenerational), multiple crustacean species, and the toxic mechanisms. In this study, a thorough literature review was performed to summarize the ecotoxicological data of APIs tested on a range of invertebrates. Therapeutic classes including antidepressants, anti-infectives, antineoplastic agents, hormonal contraceptives, immunosuppressants, and neuro-active drugs exhibited higher toxicity to crustaceans than other API groups. The species sensitivity towards APIs exposure is compared in D. magna and other crustacean species. In the case of acute and chronic bioassays, ecotoxicological studies mainly focus on the apical endpoints including growth and reproduction, whereas sex ratio and molting frequency are commonly used for evaluating the substances with endocrine-disrupting properties. The multigenerational and "Omics" studies, primarily transcriptomics and metabolomics, were confined to a few API groups including beta-blocking agents, blood lipid-lowing agents, neuroactive agents, anticancer drugs, and synthetic hormones. We emphasize that in-depth studies on the multigenerational effects and the toxic mechanisms of APIs on the endocrine systems of freshwater crustacean are warranted. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023

Research Area(s)

  • Aquatic invertebrates, Species sensitivity, Multigenerational effects, Transcriptomics, Metabolomics, SEROTONIN REUPTAKE INHIBITORS, LIFE-HISTORY TRAITS, 6 ANTICANCER DRUGS, DAPHNIA-MAGNA, CHRONIC TOXICITY, TRANSGENERATIONAL TOXICITY, ANTIDEPRESSANT FLUOXETINE, HORMONE BIOSYNTHESIS, ENDOCRINE DISRUPTION, AQUATIC ORGANISMS

Citation Format(s)

Freshwater crustacean exposed to active pharmaceutical ingredients: ecotoxicological effects and mechanisms. / Guo, Jiahua; Ren, Jingya; Chang, Chao et al.
In: Environmental Science and Pollution Research , Vol. 30, No. 17, 04.2023, p. 48868–48902.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review