Freeze-drying of aqueous solution frozen with prebuilt pores

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

30 Scopus Citations
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Author(s)

Detail(s)

Original languageEnglish
Pages (from-to)2048-2057
Journal / PublicationAICHE Journal
Volume61
Issue number6
Publication statusPublished - 1 Jun 2015
Externally publishedYes

Abstract

To save drying time and increase productivity, a novel idea was proposed for freeze-drying of liquid materials by creating an initially unsaturated frozen structure. An experimental investigation was carried out aiming at verifying the idea using a multifunctional freeze-drying apparatus. Mannitol was selected as the primary solute in aqueous solution. Liquid nitrogen ice-cream making method was used to prepare the frozen materials with different initial porosities. Results show that freeze-drying can be significantly enhanced with the initially unsaturated frozen material, and substantial drying time can be saved compared with conventional freeze-drying of the initially saturated one. Drying time was found to decrease with the decrease in the initial saturation. The drying time for the initially unsaturated frozen sample (S0=0.28 or 0.69 of initial porosity) can be at best 32% shorter than that required for the saturated one (S0=1.00 or zero porosity). This unique technique is easy to implement and improves the freeze-drying performance of liquid materials.

Research Area(s)

  • Freeze-drying, Initial saturation, Liquid material, Prebuilt pore, Unsaturated

Bibliographic Note

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Citation Format(s)

Freeze-drying of aqueous solution frozen with prebuilt pores. / Wang, Wei; Hu, Dapeng; Pan, Yanqiu et al.
In: AICHE Journal, Vol. 61, No. 6, 01.06.2015, p. 2048-2057.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review