Freehand scanning photoacoustic microscopy with simultaneous localization and mapping
Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Author(s)
Related Research Unit(s)
Detail(s)
Original language | English |
---|---|
Article number | 100411 |
Journal / Publication | Photoacoustics |
Volume | 28 |
Online published | 7 Oct 2022 |
Publication status | Published - Dec 2022 |
Link(s)
DOI | DOI |
---|---|
Attachment(s) | Documents
Publisher's Copyright Statement
|
Link to Scopus | https://www.scopus.com/record/display.uri?eid=2-s2.0-85139591263&origin=recordpage |
Permanent Link | https://scholars.cityu.edu.hk/en/publications/publication(6282dc36-f2e7-4c08-8049-c74214200ff7).html |
Abstract
Optical-resolution photoacoustic microscopy offers high-resolution, label-free hemodynamic and functional imaging to many biomedical applications. However, long-standing technical barriers, such as limited field of view, bulky scanning probes, and slow imaging speed, have limited the application of optical-resolution photoacoustic microscopy. Here, we present freehand scanning photoacoustic microscopy (FS-PAM) that can flexibly image various anatomical sites. We develop a compact handheld photoacoustic probe to acquire 3D images with high speed, and great flexibility. The high scanning speed not only enables video camera mode imaging but also allows for the first implementation of simultaneous localization and mapping (SLAM) in photoacoustic microscopy. We demonstrate fast in vivo imaging of some mouse organs, and human oral mucosa. The high imaging speed greatly reduces motion artifacts and distortions from tissue moving, breathing, and unintended handshaking. We demonstrate small-lesion localization in a large region of the brain. FS-PAM offers a flexible high-speed imaging tool with an extendable field of view, enabling more biomedical imaging applications.
Research Area(s)
- Expendable field of view, Freehand-scanning, Optical-resolution, Photoacoustic microscopy
Citation Format(s)
Freehand scanning photoacoustic microscopy with simultaneous localization and mapping. / Chen, Jiangbo; Zhang, Yachao; Zhu, Jingyi et al.
In: Photoacoustics, Vol. 28, 100411, 12.2022.Research output: Journal Publications and Reviews (RGC: 21, 22, 62) › 21_Publication in refereed journal › peer-review
Download Statistics
No data available