Formation of molecular radical cations of enkephalin derivatives via collision-induced dissociation of electrospray-generated copper (II) complex ions of amines and peptides

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

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Author(s)

  • Ivan K Chu
  • Christopher F Rodriguez
  • Alan C Hopkinson
  • Tai-Chu Lau

Detail(s)

Original languageEnglish
Pages (from-to)1114-1119
Journal / PublicationJournal of the American Society for Mass Spectrometry
Volume12
Issue number10
Publication statusPublished - 2001

Abstract

Fragmentation of some electrospray-generated complex ions, [63CuII(amine)M]·2+, where M is an enkephalin derivative, produces the radical cation of the peptide, M·+. This ion has only been observed when M contains a tyrosyl or tryptophanyl residue plus a basic residue, typically arginyl or lysyl. A typical viable amine is diethylenetriamine. Collision-induced dissociation (CID) of the M·+ ion yields a prominent [M - 106]·+ product ion for tyrosine-containing peptides, and a prominent [M - 129]·+ ion for a tryptophan-containing peptide. These fragment ions are formed as a result of elimination of the tyrosyl and tryptophanyl side chains. Dissociation of these ions, in turn, produces second generation product ions, many of which are typically absent in the fragmentation of protonated peptide ions. Structures for some of these unusual ions are proposed. Copyright © 2001 American Society for Mass Spectrometry.

Citation Format(s)

Formation of molecular radical cations of enkephalin derivatives via collision-induced dissociation of electrospray-generated copper (II) complex ions of amines and peptides. / Chu, Ivan K; Rodriguez, Christopher F; Hopkinson, Alan C et al.
In: Journal of the American Society for Mass Spectrometry, Vol. 12, No. 10, 2001, p. 1114-1119.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review