Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

30 Scopus Citations
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Author(s)

  • Shini Feng
  • Huijie Zhang
  • Sha Xu
  • Hideki Nakanishi
  • Xiao-Dong Gao

Detail(s)

Original languageEnglish
Pages (from-to)552-560
Journal / PublicationMaterials Science and Engineering C
Volume96
Online published28 Nov 2018
Publication statusPublished - Mar 2019

Abstract

Biomedical application of boron nitride (BN) nanomaterials has recently attracted considerable attentions. BN nanospheres (BNNS) could safely deliver anti-cancer drug into tumor cells, which makes them potential nanocarrier for cancer therapy. However, the poor dispersity in physiological environments and low drug loading capacity severely limit their further applications. Herein, we developed a novel drug delivery system based on folate-conjugated mesoporous silica (MS)-functionalized BNNS (BNMS-FA). Dispersity and drug loading capacity of BNNS were highly improved by MS modification. BNMS-FA complexes were nontoxic up to a concentration of 100 μg/mL, and could be specifically internalized by HeLa and MCF-7 cells via folate receptor-mediated endocytosis. Doxorubicin (DOX) could be loaded onto BNMS-FA complexes with high efficiency via π-π stacking and hydrogen bonding, and showed a sustained release pattern under different pH conditions. BNMS-FA/DOX complexes exhibited superior drug internalization and antitumor efficacy over free DOX, BNNS/DOX and BNMS/DOX complexes, which were considered promising for targeted cancer therapy.

Research Area(s)

  • Boron nitride nanospheres, Cancer therapy, Doxorubicin, Mesoporous silica, Targeted delivery

Citation Format(s)

Folate-conjugated, mesoporous silica functionalized boron nitride nanospheres for targeted delivery of doxorubicin. / Feng, Shini; Zhang, Huijie; Xu, Sha et al.
In: Materials Science and Engineering C, Vol. 96, 03.2019, p. 552-560.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review