Folate-bovine serum albumin functionalized polymeric micelles loaded with superparamagnetic iron oxide nanoparticles for tumor targeting and magnetic resonance imaging

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review

74 Scopus Citations
View graph of relations

Author(s)

  • Huan Li
  • Kai Yan
  • Yalei Shang
  • Lochan Shrestha
  • Rufang Liao
  • Fang Liu
  • Penghui Li
  • Haibo Xu
  • Zushun Xu

Detail(s)

Original languageEnglish
Pages (from-to)117-126
Journal / PublicationActa Biomaterialia
Volume15
Online published13 Jan 2015
Publication statusPublished - 15 Mar 2015

Abstract

Polymeric micelles functionalized with folate conjugated bovine serum albumin (FA-BSA) and loaded with superparamagnetic iron oxide nanoparticles (SPIONs) are investigated as a specific contrast agent for tumor targeting and magnetic resonance imaging (MRI) in vitro and in vivo. The SPIONs-loaded polymeric micelles are produced by self-assembly of amphiphilic poly(HFMA-co-MOTAC)-g-PEGMA copolymers and oleic acid modified Fe3O4 nanoparticles and functionalized with FA-BSA by electrostatic interaction. The FA-BSA modified magnetic micelles have a hydrodynamic diameter of 196.1 nm, saturation magnetization of 5.5 emu/g, and transverse relaxivity of 167.0 mM-1 S-1. In vitro MR imaging, Prussian blue staining, and intracellular iron determination studies demonstrate that the folate-functionalized magnetic micelles have larger cellular uptake against the folate-receptor positive hepatoma cells Bel-7402 than the unmodified magnetic micelles. In vivo MR imaging conducted on nude mice bearing the Bel-7402 xenografts after bolus intravenous administration reveals excellent tumor targeting and MR imaging capabilities, especially at 24 h post-injection. These findings suggest the potential of FA-BSA modified magnetic micelles as targeting MRI probe in tumor detection.

Research Area(s)

  • Amphiphilic copolymers, Folate, Magnetic micelles, Magnetic resonance imaging, Tumor

Citation Format(s)

Folate-bovine serum albumin functionalized polymeric micelles loaded with superparamagnetic iron oxide nanoparticles for tumor targeting and magnetic resonance imaging. / Li, Huan; Yan, Kai; Shang, Yalei et al.
In: Acta Biomaterialia, Vol. 15, 15.03.2015, p. 117-126.

Research output: Journal Publications and ReviewsRGC 21 - Publication in refereed journalpeer-review