FMSM : A novel computational model for predicting potential miRNA biomarkers for various human diseases

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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Author(s)

  • Yiwen Sun
  • Zexuan Zhu
  • Zhu-Hong You
  • Zijie Zeng
  • Yu-An Huang

Related Research Unit(s)

Detail(s)

Original languageEnglish
Article number121
Journal / PublicationBMC Systems Biology
Volume12
Issue numberSupplement 9
Online published31 Dec 2018
Publication statusPublished - 2018

Conference

Title29th International Conference on Genome Informatics (GIW 2018)
LocationKunming University of Science and Technology
PlaceChina
CityYunnan
Period3 - 5 December 2018

Link(s)

Abstract

Background: MicroRNA (miRNA) plays a key role in regulation mechanism of human biological processes, including the development of disease and disorder. It is necessary to identify potential miRNA biomarkers for various human diseases. Computational prediction model is expected to accelerate the process of identification.

Results: Considering the limitations of previously proposed models, we present a novel computational model called FMSM. It infers latent miRNA biomarkers involved in the mechanism of various diseases based on the known miRNA-disease association network, miRNA expression similarity, disease semantic similarity and Gaussian interaction profile kernel similarity. FMSM achieves reliable prediction performance in 5-fold and leave-one-out cross validations with area under ROC curve (AUC) values of 0.9629+/- 0.0127 and 0.9433, respectively, which outperforms the state-of-the-art competitors and classical algorithms. In addition, 19 of top 25 predicted miRNAs have been validated to have associations with Colonic Neoplasms in case study.

Conclusions: A factored miRNA similarity based model and miRNA expression similarity substantially contribute to the well-performing prediction. The list of the predicted most latent miRNA biomarkers of various human diseases is publicized. It is anticipated that FMSM could serve as a useful tool guiding the future experimental validation for those promising miRNA biomarker candidates.

Research Area(s)

  • Biomarker, Computational prediction, Expression profiles, MiRNA-disease association

Citation Format(s)

FMSM : A novel computational model for predicting potential miRNA biomarkers for various human diseases. / Sun, Yiwen; Zhu, Zexuan; You, Zhu-Hong; Zeng, Zijie; Huang, Zhi-An; Huang, Yu-An.

In: BMC Systems Biology, Vol. 12, No. Supplement 9, 121, 2018.

Research output: Journal Publications and Reviews (RGC: 21, 22, 62)21_Publication in refereed journalpeer-review

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