Fluorescent probes for detecting monoamine oxidase activity and cell imaging

Xuefeng Li; Huatang Zhang; Yusheng Xie; Yi Hu; Hongyan Sun; Qing Zhu

doi:10.1039/c3ob42326c

Fluorescent probes for detecting monoamine oxidase activity and cell imaging

Xuefeng Li, Huatang Zhang, Yusheng Xie, Yi Hu, Hongyan Sun, Qing Zhu

Research output: Journal Publications and Reviews › RGC 21 - Publication in refereed journal › peer-review

45 Citations (Scopus)

Abstract

A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL^-1 respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells. © 2014 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	2033-2036
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	13
Online published	28 Jan 2014
DOIs	https://doi.org/10.1039/c3ob42326c
Publication status	Published - 7 Apr 2014

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title = "Fluorescent probes for detecting monoamine oxidase activity and cell imaging",

abstract = "A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL-1 respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells. {\textcopyright} 2014 The Royal Society of Chemistry.",

author = "Xuefeng Li and Huatang Zhang and Yusheng Xie and Yi Hu and Hongyan Sun and Qing Zhu",

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TY - JOUR

T1 - Fluorescent probes for detecting monoamine oxidase activity and cell imaging

AU - Li, Xuefeng

AU - Zhang, Huatang

AU - Xie, Yusheng

AU - Hu, Yi

AU - Sun, Hongyan

AU - Zhu, Qing

PY - 2014/4/7

Y1 - 2014/4/7

N2 - A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL-1 respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells. © 2014 The Royal Society of Chemistry.

AB - A series of new fluorogenic probes for monoamine oxidases (MAOs) were reported based on an oxidation and β-elimination mechanism. The limits of detection of the probes for MAO-A and -B were determined to be 3.5 and 6.0 μg mL-1 respectively. These probes displayed strong activity towards MAOs, especially MAO-B. Cellular imaging studies were also successfully conducted with MCF-7 cells. © 2014 The Royal Society of Chemistry.

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U2 - 10.1039/c3ob42326c

DO - 10.1039/c3ob42326c

M3 - RGC 21 - Publication in refereed journal

C2 - 24553601

SN - 1477-0520

VL - 12

SP - 2033

EP - 2036

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 13

ER -

Fluorescent probes for detecting monoamine oxidase activity and cell imaging

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